The Clinical Research On Ischemic Stroke With Mild Vascular Cognitive Impairment Of Pi Shen Yang Xu Xing Trested With Wen-yang-tong-mai Keli

Objective To observe and research the clinical efficacy of Wen Yang Tong Mai Ke Li treatment of ischemic stroke with mild vascular cognitive impairment of Pi-ShenYang-Xu Xing in patients, for the clinical use of traditional Chinese medicine and integrative medicine treatment of vascular cognitive impairment and provide a reliable theoretical basis and clinical evidence.Methods A total of 60 patients with ischemic stroke with mild vascular cognitive impairment in patients was divided into groups randomized followed by the treatment with Wen Yang Tong Mai Keli treatment group and Jin Gui Shen Qi Wan matched group,30 cases in each group.The patients in the treatment groupuse Wen Yang Tong Mai Keli and Nicergoline Capsules for the treatment.The patients in the control group use Jin Gui Shen Qi Wan and Nicergoline Capsules for the treatment.Except for basic treatment respectively.Observed the changes of Mo CA scores,amplitude and latency of P300,ADL scores,TCM syndrome and the occurrence of adverse events before and after treatment 6 weeks and 12 weeks.Results(1)Clinical assessment:â‘  Clinical efficacy :The total effective rate of Wen Yang Tong Mai Keli treatment group was 88.46%,and the control group is 75.0%, there was statistically significant difference comparing the two groups(P<0.05),which suggested that the total clinical efficacyt of Wen Yang Tong Mai granule treatment group is better than the control group.â‘¡TCM syndrome efficacy : The total efficiency rate of the Wen Yang Tong Mai Keli treatment group was 92.3%,and the control group is 85.71%,there was statistically significant difference comparing the two groups,which suggested that Wen Yang Tong Mai Keli treatment group is better than the control group in improving aspects ofTCM syndrome.(2)Symptomatic index evaluation:â‘ Cognitive function: Two groups of patients before treatment Mo CA score,P300 latency and amplitude was not statistically significant,and the differences between these indicators change at 6 weeks after treatment were also no statistically significant(P >0.05).While the differences between these indicators change at 12 weeks after treatment were statistically significant(P <0.05). After 6 weeks,the differences between two groups on Mo CA score has no statistically significant(P >0.05). But he differences between P300 latency and amplitude were statistically significant.The differences between these indicators change at 12 weeks after treatment were statistically significant(P<0.05),which suggested that the curative effect of two groups of drugs to improve cognitive function of ischemic stroke with mild vascular cognitive impairment patients have already produced, As the duration of treatment, the efficacy is more significant.And the dfficacy of the treatment group is higher than the control group.In the delayed memory, visuospatial and executive function and attention scores of these three areas,there was statistically significant difference(P< 0.05), Differences between the two groups before and after treatment there was also significant.Which suggested that the treatment of two groupse can both improve the scores in the delayed memory,visuospatial and executive function and attention.And the efficacy of treatment group is better than the control group.â‘¡ Activities of daily living: Compared with the previous treatment,the ADL scores of two groups of patients changes at 6 weeks were no statistically significant(P >0.05),but the difference after 12 weeks of treatment were statistically significant(P<0.05).The differences between the two groups after treatment at 6 weeks ande 12 weeks,there was no significant(P >0.05),which suggested that the efficacy of two drugs to improve activities of daily living of patients are considerable. And compared between the two groups, the effect is quite.â‘¢ TCM syndrome scores: Compared with the previous treatment,the TCM syndromescores of two groups of patients changes at 6 weeks and 12 weeks were both statistically significant(P <0.05), and the difference between 6 weeks of treatment and12 weeks treatment was also statistically significant(P <0.05),which suggested that two drugs are effective in improving TCM symptoms of ischemic stroke with mild cognitive impairment patients.And as the duration of treatment, the efficacy is more significant. The TCM syndrome scores of two groups of patients changes at 6 weeks were no statistically significant(P >0.05).The TCM syndrome scores of two groups of patients changes at 12 weeks were statistically significant(P<0.05),which suggested that the treatment group is better than the control group in improving TCM symptoms of ischemic stroke with mild cognitive impairment patients at 12 weeks.(3) Safety index:During the treatment and follow-up,through to observe the drug toxicity after two groups of patients taking the drug,two groups were not adverse reactions.The blood routine,urine routine,stool routine,liver and kidney function,electrolytes and ECG and other safety indicators on two groups after the treatment are no statistically significant. which suggested that taking both drugs are safe.Conclusion The Wen Yang Tong Mai Keli joint nicergoline treatment of ischemic stroke with mild vascular cognitive impairment with Pi-Shen-Yang-Xu Xing in patients have the significant effect.The drug can improve cognitive function in patients and activities of daily living.There is also no adverse reactions and side effects during treatment.It is a safe and effective drug,which use to treat ischemic stroke with mild vascular cognitive impairment of Pi-Shen-Yang-Xu Xing, so it is worthy of clinical application and promotion.