The Effect Of Sulfate Etimicin On Renal Function In Hospitalized Patients Abstract

ObjectiveTo observe the effect of Sulfate Etimicin on renal function in hospitalized patients, evaluate the role of factors, such as age, gender, high blood pressure,diabetes,diuretic, cardiovascular disease, chronic renal insufficiency, other antimicrobial drugs in combination, antihypertensive drugs of ARB or ACEI, in the renal function injury induced by sulfate etimicin to analyze the risk factors. To provide a theoretical basis for clinical to choice right regiment, dose and medication monitoring.MethodAccording to the experimental design, we collected 986 cases of hospitalized patients treated with sulfate etimcin from July 1,2012 to May 1,2014 through computer database system. We exclused patients who exam renal function once in 464 cases, treat with sulfate etimcin less than 2 days in 89 cases, exam renal function more than 2 weeks after treatment and history in not complete in 368 cases, and get 65 cases of patients included. Detailed records of patients with the history, basic condition, treatment process, inspection and other information, including gender, age, concomitant medications, diseases before and after the treatment serum creatinine, urea, uric acid, beta 2 microglobulin. According to before and after the treatment, Scr patients were divided into Scr high group (n=36) and Scr normal group(n=24). Then we according to the Amsterdam AKI criteria, we divided patients into AKI group(n=6) and non-AKI group(n=59). The experimental results are indicated with Mean±SD. Statistical analysis was performed by SPSS16.0.Results1.In the 36 cases with creatinine increased after Sulfate Etimicin anti-infection treatment, the Scr was increased from 64.02 ± 19.36 umol/L to 75.16 ± 25.92 umol/L(P<0.05), eGFR decreased from 120.11 ± 48.13 umol/L to 104.70 ± 42.41 umol/L(P<0.05), Urea increased from 5.73 ± 2.55mg/dL to 7.35 ± 4.14 mg/dL(P <0.05)., Urinary protein (qualitative analysis) decrease (P<0.05), Uric acid, β2-microglobulin no changes (P> 0.05).2. Univariate analysis showed that diabetes, diuretics may apply in accordance with the patient after treatment induced etimicin associated with elevated serum creatinine (P<0.05), age, gender, hypertension, cardiovascular disease, chronic renal insufficiency, combined with other antimicrobial drug, ARB or ACEI class antihypertensive drugs, QingKaiLing (P> 0.05); possible related factors mentioned above included multivariate logistic regression model analysis showed that diabetes, diuretics may apply depending on the risk factors for post-meter elevated serum creatinine star.3. Univariate analysis showed that diabetes, diuretics may apply in accordance with the patient after treatment induced etimicin associated with elevated serum creatinine increased (P<0.05), age, gender, hypertension, cardiovascular disease, chronic renal insufficiency, combined with other antimicrobial drug, ARB or ACEI class antihypertensive drugs, QingKaiLing (P>0.05)4. Univariate analysis showed that hypertension may apply depending etimicin after treatment induced acute kidney injury associated (P<0.05).Conclusion1. diabetes and the use of diuretics is a risk factor for patients according to treatment after etimicin elevated serum creatinine.2. Diabetes, cardiovascular disease is elevated serum creatinine after the magnitude of the impact of medication factors.3. hypertension is etimicin that induced acute kidney injury risk factors.