Meta-analysis Of Risk Factors Of Cholelithiasis In China

BCAKGROUNDS AND OBJECTIVE:Cholelithiasis(GallstoneDisease, GD) is a common disease in our country. Due to the cholesterol in bile, cholochrome, adhesive and other ingredients live together for a long time, they finally precipitate into stone. According to the variation of stone component content, Cholelithiasis can be divided into cholesterol stones, bile pigment stones and mixed stones. According to the different position of lithogenesis,gallstones can be divided into the gallbladder stones, extrahepatic bile duct stones and intrahepatic bile duct stones. Cholelithiasis patients can easily occurred with bile duct infection, obstructive jaundice, and closely related with bile duct cancer. So it’s extremely important in our lives as for explorating the risk factors of Cholelithiasis.There is large difference about the incidence of Cholelithiasis.The incidence of people up to 9-10% in our country, and the incidence of natural population was 7.8%, so our country residents need do a lot of research to study the causes that why we have a higher incidence. Theories tell us the reason could be related to the lifesyle and geographical factors of our country residents. In recent years, its incidence has a tendency to rise because of our diet styles and lifestyle changing. In order to develop a better strategy in prevention, the author make a meta analysis of the risk factors of Cholelithiasis in China by comprehensive evaluation of articles published in the domestic and abroad.METHODS:Collect 30 articles about common risk factors of cholelithiasis of Chinese through independent case-control study published in the domestic and abroad since 1987-2014 and make a quantitative comprehensive analysis,then do a test for heterogeneity test and calculate the OR value and its 95% confidence interval by using Stata 12.0.RESULTS:family history of GD:OR=2.73 (2.22,3.35), alcohol drinking:OR=1.53(1.20,1.97), the history of biliary tract roundworm:OR=5.28(3.10,9.00),past history of biliary tract infection:OR=28.50(19.22,42.26), BMI>25kg/m2:OR=1.70(1.51,1.92), greasy food: OR=3.27(1.76,6.07), non-vegetarian diet:OR=2.03(1.48,2.77), hyperlipemia: OR=2.26(1.88,2.71), menopause:OR=3.25(2.49,4.24) and multiple pregnancies: OR=1.56(1.29,1.88).Above all are the risk factors of GD in China, we should control these factors to prevent the occurrence. Besides those, milk drinking: OR=0.43(0.34,0.55)and regular breakfast:OR=0.19(0.06,0.64)can be thought as protective factors in our country. Tea drinking:OR=0.73(0.41,1.28),smoking:OR=0.86 (0.51,1.45),vegetarian diet:OR=0.24(0.05,1.13)and going to bed after 22:00: OR=0.93(0.24,3.67)may be GD’s protective factors, but it’s not statistically significant. CONCLUSION:If we try to adjust dietary habits, eat breakfast, drink milk, make reasonable weight loss,drink less and avoid ascaris infection,maybe it’s good to prevent the happen of the cholelith disease.