Chronic Cerebral Hypoperfusion And Cerebral White Matter Damage Andmild Cognitive Impairment Correlation

ObjectiveThrough imaging methods, quantify the extent of the Cerebral white matter damage and the chronic cerebral hypoperfusion. Researching the relationship of the chronic cerebral hypoperfusion, Cerebral white matter damage and mild cognitive impairment, to supply the new idea for the clinical diagnosis of chronic cerebral hypoperfusion, and supply the evidence to helping the early intervention and medications of cognitive dysfunction. Methods(1)For all selected cases based on history to rule out other diseases which can cause damage to the white matter; within the last three months without new-onset stroke events; based on laboratory tests to exclude secondary cognitive dysfunction; using MMSE and ADL exclude dementia; HAMD exclude depression.(2)By brain magnetic resonance angiography, CT brain perfusion imaging and MR perfusion weighted imaging confirmed intracranial, extra cranial vascular stenosis or significantly reduced blood flow to the brain 20 patients with chronic cerebral hypo perfusion group, which 11 males and 9 females the average age(74.8±6.5).Same period of treatment in hospital care neurology no obvious neurological disease, brain through magnetic resonance angiography, CT brain perfusion imaging and perfusion-weighted magnetic resonance imaging confirmed intracranial, extra cranial vascular stenosis or whole without obvious no significant changes in cerebral blood flow in 22 patients, the control group, of which 10 males and 12 females the average age(74.0±6.7).(3)Performed on selected cases of white matter injury score(based on the white matter in the Rotterdam Study of qualitative methods to develop methods and Fazekas Scale score semiquantitative evaluation form), Montreal Cognitive Assessment(Montreal Cognitive Assessment Mo CA) scores. Analyzed using SPSS 13.0 for Windows statistical software for its relevance. Results(1)The contradistinction between chronic cerebral hypoperfusion group and the control group: White matter lesion scores were significantly statistical significance; Montreal Cognitive Assessment score significantly higher statistical significance.(2)Chronic cerebral hypoperfusion group and the control group of patients in visuospatial and executive function, language, abstract, delayed recall and other cognitive domains and naming, note that the definition of cognitive domains compared to the differences more pronounced. Conclusion(1)Chronic cerebral hypoperfusion in patients with a high degree of Cerebral white matter damage, cognitive impairment heavy. Assessment of chronic cerebral Cerebral white matter damage may reflect the degree of hypoperfusion. Chronic cerebral hypoperfusion can lead to cognitive dysfunction.(2)Chronic cerebral hypoperfusion in patients with varying degrees of damage to the field of cognitive functions are not entirely consistent, chronic cerebral hypoperfusion group of patients with visuospatial and executive function, language, abstract, delayed recall the extent of the damage and other cognitive domains compared named the extent of damage, note that the definition of cognitive domains more pronounced. Consider the one hand, cerebral blood flow in the brain unevenly distributed, so different brain tissue hypoperfusion sensitivity differences lead to different degrees of brain damage; hand cerebral blood flow changes in energy metabolism in different parts of lead different. These are to be further explored. Key words:Chronic cerebral hypoperfusion, Cerebral white matter damage, mild...