High Insulin Levels Caused Obesity With Related Mechanism Research

Objective: Obesity is an important risk factor leading to type 2 diabetes and cardiovascular disease.The elderly patients with Type 2 Diabetes because of difference of life and diet condition, there are differences in glucose control situation.The quality of glycemic control can be indirectly represented by glycated blood protein.There is certain connection between obesity and basal insulin levels.If there is a correlation between the level of insulin and obesity?The stand or fall of glycemic control on insulin levels tend to from what is the correlation between obesity.This study was designed to observe the impact of type 2 diabetes with different fasting insulin casued obesity,and poor glycemic control with different fasting insulin casued obesity.Method: For January 2014 to June 2014 in the First Affiliated Hospital of Zhengzhou University,Department of Endocrinology and Geriatric Endocrinology 278 cases hospitalized elderly patients with diabetes measured Hb A1 c.The Hb A1 c values are divided by the level of glycemic control normal group G1 group(Hb A1c≤6.5%)and poor glycemic control group G2 group(6.5%<Hb A1c≤8.5%).Fasting insulin is greater than 7.1u U/m L is divided into normal glycemic control high insulin levels group(G1HI), normal glycemic control low insulin levels(G1LI),poor glycemic control high insulin levels(G2HI),poor glycemic control low insulin levels(G2LI). The patient was measured height,weight and body mass index(BMI).BMI were compared in the high insulin levels group and the low insulin levels group.BMI were compared in the four groups,and we analysis the relationship between insulin andobesity in different glycemic control group.Results: 1.278 cases of type 2 diabetes have 151 men cases and 127 women cases,the average age of men(68.9±8.9) years,the average age of women(67.3±7.3)years. G1 group BMI(25.58±4.11)kg/m2,G2 group BMI(27.89±3.69)kg/m2;G1 group FINS(8.31±6.26)u U/m L,G2 group FINS(7.96±4.51)u U/m L;G1 group Hb A1c(6.09±3.48)%,G2 group Hb A1c(7.47±0.56)%; 2.HI group and LI group compared to the group of BMI((P<0.035);G1HI group and G1 LI compared to the group of BMI(P=0.034);G1HI group and G1 LI compared to the group of BMI(P=0.042);Regardless of glycemic control the higher of the basic insulin levels,the more easily lead to obesity; 3.Pearson correlation analysis of insulin and BMI in the G1 group and G2 group.Worse glycemic control,the more easily lead to obesity.Conclusions: In elderly diabetic patients the higher basal insulin levels in vivo,the greater correlation with obesity.The higher basal insulin worse glycemic control,more likely to cause obesity.Objective: High insulin levels easily lead to obesity, and cause chronic diseases such as type 2 diabetes, cardio-cerebrovascular disease.By what mechanism insulin lead to obesity in domestic literature rarely raised.This article mainly discusses the high level of insulin through intervention mechanisms in the body which cause the occurrence of obesity.Methods: The 60 six-week-old male C57BL/6J mice were fed one week adaption. After 8 hours of fasting, the blood was collected with angular wein. Blood was collected by centrifugation, serum was collected.Determination of serum insulin, according to the level of insulin into the high levels of insulin group(HI) and low levels of insulin group(LI) each 30.HI group and LI group were randomly divided into two groups-fat diet group and normal diet group, each 15.Fat diet group fed high-fat diet, normal diet group fed the basal diet. Every two weeks body weight were weighed and recored. Weight changes were observed in mice by results.After 12 weeks, the mice weight were weighed and recorded. The mice were sacrificed by cervical dislocation. By eyeball blood, serum was collected by centrifugation.We measured serum insulin levels and serum obestatin levels.The visceral adipose tissue weighted were weighed and recored. Comparison of both insulin and diet in mice cause weight relationships, analyze the relationship between obesity hormone suppression and obesity.Results: 1 High insulin-high-fat diet group body weight and visceral adipose tissue weight was significantly higher than high insulin-normal diet group,low insulin-fatdiet group, low insulin-normal diet group(P<0.05);High insulin-normal diet group the body weight and visceral adipose tissue weight than the low insulin-normal diet group(P<0.05); Low insulin-fat diet group the body and visceral adipose tissue weight than high insulin-normal diet group(P<0.05).It is proved that insulin and fat diet both lead to obesity,fat diet is more likely cause obesity. 2 High insulin-high fat diet group obestatin was significantly lower than high insulin-normal diet group,low insulin-fat diet group, low insulin-normal diet group(P<0.05); High insulin-normal diet group the obestatin lower than the low insulinnormal diet group(P<0.05); Low insulin-fat diet group the obestatin lower than high insulin-normal diet group(P<0.05).Neagtively related to obesity and obeatatin.Conclusions: High insulin levels and fat diet both lead to obesity,but the greater role is the fat diet.High insulin levels and fat diet both reduce the obestatin,it is indicated that obeatatin and obesity is a relationship.