The Effect Of Eye Movement Function And Executive Function Of Ziprasidone On The First-episode Schizophrenia

Objective:1 Investigation the effect of eye movement function and executive function of ziprasidone in the treatment of the first-episode schizophrenia.2 For further providing evidence that ziprasidone could improve cognitive function in schizophrenia.Methods:79 the first-episode schizophrenic inpatients who were accorded with international classification of Diseases, tenth version(ICD-10) were divided into Ziprasidone group(n=42) and Risperidone group(n=37) randomly to treat for 8 weeks. Meanwhile exploratory eye movement(EEM) and wisconsin card sorting test(WCST) were used to evaluate respectively.Results:1 The results of EEM showed that ziprasidone and risperidone groups improved number of eye fixation(NEF) of the first-episode schizophrenic inpatients after 4 weeks of treatment(P > 0.05), while ziprasidone and risperidone groups improved significantly NEF of schizophrenic inpatients after 8 weeks of treatment(P < 0. 01).The results of responsive search score(RSS) showed that ziprasidone and risperidone groups were significantly higher than baseline after 4 weeks of treatment(P<0.01), while ziprasidone and risperidone groups improved significantly RSS of schizophrenic inpatients after 8 weeks of treatment(P < 0. 01).The results of discriminant(D) showed that ziprasidone and risperidone groups were significantly lower than baseline after 4 weeks of treatment(P<0.01), while ziprasidone and risperidone groups improved significantly D(Down to a negative scores) of schizophrenic inpatients(P < 0. 01). Moveever, D of ziprasidone that is-0.65±1.70 were low to D of risperidone that is-0.65±1.70 after 8 weeks of treatment, but there was no significantly difference.2 The results of wisconsin card sorting test(WCST) showed that the inpatient groups were both executive dysfunction and were not statistically significant. Compared with the baseline group, the total number of tests, the number of errors and random errors of schizophrenic inpatients decreased significantly after 4 weeks and 8 weeks of treatment with ziprasidone or risperidone(P<0.01), while number of correct responses and classifications completed increased significantly(P<0.01).Compared with risperidone group, the number of random errors of schizophrenic inpatients decreased significantly after 4 weeks and 8 weeks of treatment with ziprasidone(P<0.05).Conclusions:1 Ziprasidone could be impact on eye movements in the first-episode schizophrenia, and the D scores of most of the inpatients were negative scores after 8 weeks of treatment with ziprasidone. The results show that eye movement function in patients were close to a normal eye function after 8 weeks of treatment with ziprasidone, and the inpatients were not the state of schizophrenia disorders. Still, there were objections to auxiliary diagnostic practices of D scores. C group, eye movements of schizophrenic inpatients were no significantly difference after 4 weeks and 8 weeks of treatment with ziprasidone(P>0.05).2 The first-episode schizophrenic patients were impaired with executive function, ziprasidone had significant effect on improving impaired executive function in the first-episode schizophrenia compared with risperidone.3 Ziprasidone is an effective antipsychotic drugs, and is worthy of wide clinical application and promotion.