Osteoprosis In Men With Diabetes, Rheumatoid Disease,kidney Disease And Fracture Risk In Clinical Research

Aims: Recently, with increasing the incidence of osteoporosis, further study of osteoporosis receives more and more attention by scholars.Although the age of occurrence in male osteoporosis is later than women, for the reason of men’s important role in social life, clear the occurrence of male osteoporosis fracture development is particularly important. Osteoporosis,rheumatoid disease, kidney disease and diabetes are all belong to the category of chronic diseases, there are complex relations among them, they influence each other. The risk of bone fracturesinduced by male patients with osteoporosis patients is bigger than women, so it provides evidence for disease recovery by analyze the disease itself and the age, body mass index(BMI), and a variety of related diseases to guide the treatment of patients with osteoporosis in the future.Methods:1014 men were selected from the Second Division of Endocrinology of the Third Hospital of Hebei Medical University, from October 2005 to July 2013. According to the WHO diagnostic criteria, the1014 subjects were divided into diabetic osteoprosis group(N=168),rheumatic group(N=229), nephrotic group(N=90), osteoprosis with fracture group(N=111). including diabetic group(N=44), rheumatic group(N=35),nephrotic group(N=20), normal group(N=156) and catamatic group(N=14)belonging to T score≥-1; diabetic group(N=90), rheumatic group(N=102),nephrotic group(N=33), normal group(N=162) and catamatic group(N=41)belonging to-2.5 < T score <-1; diabetic group(N=34), rheumatic group(N=92), nephrotic group(N=37), normal group(N=98) and catamatic group(N=56) belonging to T score≤-2.5. The bone mineral density of all subjects were measured by the dual energy x-ray absorptiometry(DEXA) scan,including L2~L4 lumbar vertebrae, both femurs(neck, great trochanter,intertrocanter and total). While age, weight, height, BMI were recorded.Statistical analyses were done by SPSS software(V13.0, SPSS Inc, USA) P<0.05 was considered statistically significant.Results:1 In diabetic osteoprosis group: No statistical difference of BMD at L2,L3, L4, RG.T, LG.T and LNeck between DM group and NC group; There was statistial difference of BMD at L2~L4, RInter, RNeck, Rtotal, LInter and Ltotal;2 In rheumatic osteoprosis group: NO statistical difference of BMD at RNeck, Rtotal, LNeck and Ltotal between rheumatic disease group and NC group. There were statistical difference(P < 0.05) of BMD at L2, L3, L4,L2~L4, RG.T, RInter, LG.T and LInter;3 In nephrotic osteoprosis group: No statistical difference of BMD at L2, L3, L4, L2~L4, RInter, RNeck, Rtotal, LInter, LNeck and Ltotal between nephropathy group and NC group;4 In osteoprosis with fracture group: There was statistical difference of BMD at L2, L3, L4, L2~L4, RG.T, RInter, RNeck, Rtotal, LG.T, LInter,LNeck and Ltotal between fractrue group and NC group.Conclusion:1 The BMD of diabetic osteoprosis group, rheumatic osteoprosis group,nephrotic osteoprosis group and osteoprosis with fracture group were lower than the normal group.2 All data was concerned with age and BMI; Advanced age was the risk factor of osteoprosis and BMI was protective factor.