Effect Of The Patients With Chronic Obstructive Pulmonary Disease With Depression By Cardiopulmonary Exercise Testing

Objective To observe the incidence of depression in patients with stable chronic obstructive pulmonary disease(COPD), and to evaluate the effect of depression in COPD by the changes in cardiopulmonary exercise testing(CPET) variables.Methods A total of eighty-five consecutive patients with stable COPD admitted to the department of cardiopulmonary rehabilitation from August 2013 to May 2014. Clinical data collection, the general clinical data: contains the patient’s name, gender, age, height,weight, smoking history, previous history, past medical history, etc., and collect the data of the static pulmonary function tests. Then Professional therapists are on site to teach patients to fill out Zung Self-Rating Depression Scale(SDS) questionnaire, and according to the results, these patients were divided into depression group and non-depression group, both of them were performed maximal exercise testing. Results A total of 26 cases of patients with depression group, accounting for 30.6% of all, the severity of depression was generally mild(mean SDS:59±7 scores). Compared with non-depression group, depressed subjects had a higher level of shortness of breath(P<0.05) despite of similar basic clinical data and levels of respiratory functional impairment. Four cases of patients quit the CPET and no one died. The peak oxygen consumption(OV&2peak) in depression group were lower, and the slope of ventilatory equivalent for carbon dioxide output(EV&/COV&2 slope) were higher than those in non-depression(P<0.05). Conclusions 1.In practice, there is a high incidence of depression in patients with stable COPD, which need to attract the attention of clinicians. 2. For the patients with COPD, CPET is safe. 3. The clinical manifestations of depression in patients with stable COPD were dyspnea at rest, ventilatory impairment during exercise. 4. Aerobic exercise capacity decreased in patients with depression,showing early appearance of muscle fatigue. 5. Decreased in ventilatory function andexercise capacity of depression in patients with stable COPD may eventually affect the quality of life and have a negative prognosis.