The Effect Of Antioxidants Supplementation On IVF/ICSI Outcome: A Meta-Analysis

Objective:To evaluate the impact of antioxidants supplementation in women undergoing IVF/ICSI treatment cycles.Methods:Searched in January 1990 to February 2015 Pubmed database、 Cochrane library、EMBASE database、VIP Chinese periodical database、Wan Fang database、The website CNKI and reference to the retrieve list of literature, and also search the Google academic.The eligible literatures which include randomized controlled trials studying the infertility women undergoing IVF/ICSI treatment cycles, comparing the outcome of antioxidant(s) supplementation versus placebo or no treatment/standard treatment. the methodological quality of the included studies was was critically appraised. Rev Man5.2 statistical software was used for Meta-analysis.Results:Eight studies was included in the meta-analysis,1285 cases of infertility patients was involved, Oral antioxidant supplementation group 794 cases,and the placebo or no treatment/standard treatment group 491 cases. Compare the outcome of oral antioxidants supplementation (including antioxidant combination agent, pentoxifylline, melatonin, L-arginine, ascorbic acid, vitamin E, vitamin C, folic acid, inositol plus folic acid) with placebo、no treatment/standard treatment. Comparison of clinical pregnancy rate, live birth rate, miscarriage rate and multiple pregnancy rate, the results show that antioxidant(s) versus placebo or no treatment/standard treatment, the clinical pregnancy rate was not significant increased[OR=1.06,95% CI (0.82-1.37), p=0.66]; live birth rate was not significant increased (OR=1.16,95% CI 0.57-2.36, P=0.68); miscarriage rate was not significant increased (OR=1.27, 95% CI 0.56-2.88, P=0.57); multiple pregnancy rate also was not significant increased (OR=0.74,95% CI 0.40-1.37, P=0.34)。Conclusion:There was no evidence that taking an antioxidant may provide benefit for infertility women undergoing IVF/ICSI treatment cycles, compare with placebo or no treatment/standard treatment, the outcome of antioxidant(s) supplementation (Including the clinical pregnancy rate, live birth rate, miscarriage rate and multiple pregnancy rate) was not significant increased, however, there did not appear to be any evidence of obvious adverse effects. At this time,there is no evidence to recommend supplemental oral antioxidants for infertility women undergoing IVF/ICSI treatment cycles.