The Expression Of THBS2 And Its Correlation With The Angiogenesis And The Long-term Prognosis Of Gastric Cancer

Objective To study THBS2 expression and VEGF, MMP ‐ 2,MMP ‐ 9 and CD34 correlations,exploring their impact on the gastric cancer angiogenesis and prognosis.Methods Using tissue microarray(156 samples)and immunohistochemical technology test the expression of THBS2, VEGF, MMP ‐ 2, MMP ‐ 9,and CD34 markers vascular endothelial cells to calculate MVD.Expression of THBS2 was tested in 40 cases of gastric cancer(OS≥10years) and 30 cases of tissues(OS≤3years) using immunohistochemistry and tissue microarray.Results The protein expression of THBS2 in 120 gastric cancer tissues is remarkably lower than 36 normal tissues(p<0.05).The protein expression of VEGF, MMP ‐2and MMP ‐9 are remarkably higher than normal tissues(p<0.05). MVD(46.52 ±19.57) in THBS2 positive expression of gastric cancer tissue significantly lower than THBS2 negative gastric cancer tissue(57.90 ±16.99)(P < 0.05).Negative correlation of THBS2 and VEGF, MMP ‐ 2,MMP ‐ 9 protein expression were found(r =‐ 0.574、‐0.447、‐0.599, P < 0.01).The protein expression of THBS2 in 40 cases of gastric cancer(OS≥10years) remarkably higher than 30 cases of tissues(OS≤3years)(p<0.05).Conclusion 1) THBS2 protein expression level in gastric cancer tissue is significantly lower than that of normal gastric mucosa tissues.2) Between THBS2 expression in gastric cancer tissue and VEGF, MMP-2,MMP-9 was significantly negative correlation, and affect the angiogenesis of gastric carcinoma. 3) THBS2 expression level may influence the angiogenesis and prognosis of gastric cancer.