The MCP-1、PTX3 Levels And Scre Observed Of Qi-boosting Blood-quickening Phlegm-dispersing Therapy On Elderly Hospital-acquired Pneumonia

Objective To observe the clinical therapeutic effects of method of promoting circulation of Qi and blood and dispersing phlegm on elderly hospital acquired pneumonia in senile patients by MCP-1, PTX3 levels and the score of observation, and observe it,s influence on the acute physiology and chronic health evaluationⅡ(APACHE-Ⅱscore), TCM symptom score, Analysis of blood gas index(Pa O2 、 Pa CO2),oxygen index(OI),lactic acid(LAC), high-sensitivity C-reactive protein(hs-CRP),PTX3 and MCP-1.We want to explore the possible mechanisms of method of promoting circulation of Qi and blood and dispersing phlegm on elderly hospital acquired pneumonia in senile patients,so it can provide objective basis for integrative medicine treatment of severe hospital acquired pneumonia.Methods We choose 60 patients diagnosed as hospitsl acquired pneumonia in senile patents in ICU in our hospital from December 2013 to December 2014(65years old of less than 90 years or youner),they were randomly divided into two groups, control group of 30 patients, the treatment group of 30 patients. the control group received Common Western treatment(antibiotics, phlegm, nutritional support, and maintain water and electrolyte balance, etc.), the treatment group received method of promoting circulation of Qi and blood and dispersing phlegm(Shen Mai injection + Sodium TanshinonⅡAsilate+Kechuanping sodium injection) on the basis of Common Western treatment.In this study, 7 days for a course, one to 7 days after treatment by APACHE- II score,TCM symptoms integral, PTX3, MCP-1 changes, changes of blood routine, blood gas analysis. By observing the APACHE- II score, TCM symptom, blood routine before and after the two treatment groups, blood gas analysis indexes( Pa O2、Pa CO2), oxygenindex(OI), serum lactic acid(LAC),high-sensitivity C-reactive protein(hs-CRP)are five poly peptide(PTX3) and monocyte chemoattractant protein-1(MCP-1) changes,clinical effect of Yiqi Huoxue Huatan method to evaluate the treatment of senile hospital acquired pneumonia, to provide scientific basis for further study.Results1. Clinical efficacy and integral indicators:The level of APACHE-Ⅱ score and TCM symptom score in the treatment group decreased significantly after treatment, compared with the control group was statistically significant(p <0.05).2.Blood gas analysis, respiratory index(OI): After treatment, reduce the level of carbon dioxide partial pressure compared with the control group, the difference between groups was statistically significant; increase the oxygen partial pressure, respiration index elevated levels, the difference between the control group and the group there was statistically significant(P <0.05).3.Serum lactate(LAC), high-sensitivity C-reactive protein(hs-CRP): after treatment compared with before treatment group, serum lactate(LAC), high-sensitivity C-reactive protein(hs-CRP) levels were statistically significantly lower, difference; there were significant differences, between the two groups after treatment comparison with the control group(P <0.05).4. Inflammatory response indicators, the treatment group after treatment, the level of MCP-1and ptx3 improved, compared with the control group was statistically significant(p <0.05).Conclusion The method of promoting circulation of Qi-boosting blood-quickening phlegm-dispersing therapy on patients with elderly hospital acquired pneumonia has obvious clinical effect. the method of promoting circulation of Qi-boostingblood-quickening phlegm-dispersing therapy can inhibite the excessive inflammatory response, Enhance immunity, enhance the immunity of the human body, depress the level of acute physiology and chronic health evaluation Ⅱand TCM symptom score,In order to achieve the purpose of treating diseases,be help to improve the prognosis of patients, and has no significant adverse drug reactions.It provides objective indicators for integrative medicine treatment of elderly hospital acquired pneumonia and reflects the the characteristic of Chinese medicine.