Effects Of Different Dosage Of Sufentanil On Hemodynamics During Anesthetic Induction With Laryngeal Mask Ventilation

[Objective]:Sufentanil is a potent narcotic analgesics, and high selectivity to specific receptor agonist, with a convenient, quick onsets, and less effect on cardiovascular and respiratory systems, no histamine release and is widely used in clinical anesthesia. Laryngeal mask is a kind of between masks and the endotracheal tube to maintain ventilation is a new type of air tools, it can be selectively used in anesthesia can also be used in the acute difficult airway, easy operation and simply maintenance. When inserting a laryngeal mask during induction of general anesthesia, to throat stimulation comparatively light, and the influence of hemodynamic and stress reaction is also smaller. Most of previous studies by sedatives narcotic analgesics muscle relaxant combined the three to study the effect of laryngeal mask for intubation hemodynamic and with the effect of muscle relaxant, the results are often poor specificity. In this study, the BIS index as the standard depth of anesthesia, using propofol to maintain under the same depth of anesthesia, to evaluate the effects of different doses of sufentanil anesthetic induction with laryngeal mask intubation on hemodynamics and provide more reasonable doses for clinical use.[Methods]:A double-blind, randomized controlled investigating methods were employed. One hundred and twenty cases with elective abdominal surgical procedure, ASA lor Ⅱ, were randomly divided into four groups:group D1, group D2, group D3 and group C (n=30, each). Group D1, D2, D3 and C were administered with different doses sufentanil :0.3μg·kg-1,0.4μg·kg-1,0.5μg·kg-1, and fentanyl 4μg·kg-1, respectively. Anesthetic induction was given propofol slowly within 30 seconds, iv. and maintenance according the BIS value (which was controlled in the range (50±5). Effect-site concentration and hemodynamic changes of propofol were recorded before drug using (TO), immediately after anesthesia induction (T1),2min after anesthesia induction (T2), immediately after laryngeal mask airway intubation(T3), 1min after laryngeal mask airway intubation (T4),3min after after laryngeal mask airway intubation (T5),5min after laryngeal mask airway intubation (T6), 10min after after laryngeal mask airway intubation (T7). The hemodynamic parameters, BIS value and the dosage of propofol at each time point were also investigated.[Results]:There was no significant difference among the four groups in gender, age, weight, height and the doses of propofol of group C, group D1, group D2 and group D3 were (5.0±1.0), (5.0±1.5), (5.0±1.1) and (5.1±0.5) mg·kg-1h-1 (P>0.05). Hemodynamic changes in group D1, D2 and D3 was with less change compared with group C during anesthetic induction (P<0.05). Hemodynamics in group D2 was more stable compared with group D1 and D3 (P<0.05). There were no serious adverse reactions among the four groups.[Conclusion]:Sufentanil (0.4 μg·kg-1) provided better hemodynamic stability during anesthetic induction with laryngeal mask intubation compare with fentanyl.