An Analysis Of Clinico-pathologic Characteristic Of Different Molecular Subtypes Of 146 Young Breast Cancer Cases

Objective:To study the Clinico-pathologic characteristics of different molecul ar subtypes of young breast cancer patients. Methods:The clinical data of 146 br ea-st cancer patients (≤40 years old)treated in Department of Breast Surgery, the can-cer hospital affiliated to Xinjiang Medical University and the Department of o ncol-ogy, Second affiliated hospital of Xinjiang Medical University, from January 2012 t-o April 2014 were retrospectively analyzed. These 146 patients, were all di agnose-d as invasive cancer. The patients were divided into less than 30 years (G roup),31 to 35 years old (Group) and 36 to 40 years old (Group), and statistical analysis of each subgroup in the clinical pathological characteristics differences; Then they were categorized into four molecular subtypes:Luminal A, Luminal B, HER2 ov-er-expressing and Basal-like, based on the expression of ER,PR,HER2 and Ki-67.T-hen analyze the differences in clinical pathological characteristics inclu ding the pat-hologic types, the number of metastatic lymph nodes, the size of the turner, histol-ogyical grading and AJCC tumor stage between different molecular subtypes. Resu-Its:In the different age groups of young breast cancer, there is no statistical diffe-rence in the pathologic type, histological grading, tumor diameter and pTNM stagi-ng. But in the axillary lymph node metastasis:less than 30 years (Group) and 31 to 35 years old (Group) compared to the 36 to 40 years old (G roup) have a high-er likely-hood of axillary lymph node metastasis, the difference was statistically si-gnificant(P<0.017).There were 24 patients in Luminal A subty pe(24/146,16.4%),77 in Luminal B subtype(77/146,52.7%),17 in Her-2 over-express ing subtype(17/146,11.6%), and 28 in Basal-like subtype(28/146,19.2%).There were statistically significant differences among different molecular subtypes regarding t he tumor size and histo-logical grade, however, there were no statistically differen ces regarding the patholo-gical type, lymph node metastasis and clinical stage. The further comparison betw-een subgroups found that the tumor size of Basal-like su btype was larger than Lu-minal A subtype(P<0.05/6) and Luminal B subtype(P< 0.05/6),On the other hand, the histological grade of Basal-like subtype was higher than Luminal A subtype(P<0.05/6) and Luminal B subtype(P<0.05/6). Over-expr ession of Her-2 type histol-ogical grading was also higher than that of Luminal ty pe A(P<0.008). Conclusion:Different molecular subtypes of young breast cancer have a statistically significant difference in some clinical pathological characteristi cs. This indicates that the diff-erent molecular subtypes may have different charact eristics in treatment and prong-osis. In addition it will provide a theoretical basis for individual treatment in brea-st cancer.