To Analyze The Principles Of Prescriptions For Senile Cognitive Impairment Based On TCM Inheritance System

Purpose:To analyze the principles of prescriptions for Cognitive impairment b y using data mining technology based on TCM inheritance system"(V2.0)"softw are, including frequency statistics, improved mutual information method, comple x system entropy clustering, no supervision of entropy clustering level without supervision. So use a scientific way to analyze the method of using the herbs, even find some new prescriptions bases on the methods to guide clinical treat ment.Methods:Collecting prescriptions which treat cognitive impairment from classic al medical books, modern journals and Xiyuan hospital. By referring to a large number of ancient books and documents which contain the therapeutic of forg etfulness and dementia, get 202 prescriptions. By retrieving documents from C NKI between 1980-2014 on the treatment of cognitive impairment (MCI/AD/Va D),get 628 prescriptions which are repeatedly screened form 23944 documents. Selection case from Xiyuan hospital outpatient and inpatient admitted to cogniti ve impairment(MCl/AD/VaD) between 2010-2014,screen 266 prescriptions. Clean sing 1096 prescriptions get structured date, which would be entried TCM Inher itance System. Analysis of categorical date get preliminary results of the basic rules of the formulas which treat cognitive impairment. And 102 prescriptions extracting from professor Zhou treatment forgetfulness patients over 60 years in XiYuan hospital out patient between 2013-2014 would be analyzed as 1096 d ates.Results:Statistics prescription drugs of treating cognitive impairment, get the h ighest frequency of three herbs:Shichangpu, Poria, Chuanxiong. Herbs of high frequency (≥100) are tonic, followed by sedative, expectorants and promoting b lood circulation TCM. Potency reflects the main directions of the herb to be ef fective treatment of cognitive impairment, Four gas (Figure 2) with warm, flat oriented Flavors (Figure 3) is mainly sweet, bitter, acrid. Meridian go up to th e liver, followed by heart, spleen and kidney. The core herb combinations are Shichangpu-turmeric-Chuanxiong-Polygala-Tuckahoe.The tonic herbs in prescriptions treatment forgetfulness and demetia of ancient literature, are higher than others from the type and frequency.The tonic, sedati ve and promoting blood circulation TCM are quite composition ratio of the hig h-frequency in journal, followed by expectorant herbs. The sedative and promot ing blood circulation TCM are higher than expectorant and tonic from the type and frequency. The promoting blood circulation TCM is the highest frequency in prescriptions treatment VaD, followed by the tonic herbs. The tonic herbs i s the highest frequency in preseriptions treatment AD,it’s the main herb for ki dney, followed by spleen.The tonic and expectorant herbs are higher than others from the type and freq uency in prescriptions treatment "sputum". The herbs of enriching the blood an d promoting blood circulation TCM are higher in prescriptions treatment "stasi s". The tonic herbs in prescriptions treatment "weak" are higher. The herbs of treatment "kidney weak" with high frequency are Dogwood, Rehmannia, wolfbe rry at el. As the highest frequency of herb, shichangpu often assemble compati bility of Chinese herbal medicine, which can soothe the nerves, promote blood circulation, benefit of spleen dampness, qi and kidney. Professor Zhou pay attention to the impact on forgetfulness of phlegm. The co re pharmaceutical compositions is berberine Wendan Tonga and Shichangpu, Al bizia, Tianma, Chuanxiong.The new combinations and prescriptions calculated in entropy clustering, part o f them originate from classic or common prescription and similar prescriptions。 Pharmaceutical compositions having anticoagulant, anti-inflammatory, antioxidant, improve cognitive function based on pharmacological studies confirmed are Th irty-seven-fleabane (Engeron)-Jiaogulan-Ginkgo Biloba,at el.Compatibility of Chinese herbal medicine with large number of new combinatio ns and prescriptions is relatively rare. Part of them are valid dates, which proy ide useful clues for found new prescriptions and deserve further experimental s tudies and clinical exploration.Conclusion:1. The potency of herbs in prescriptions treatment cognitive impairment is war m, sweet, bitter. Herbs of high frequency are tonic, sedative, promoting blood circulation TCM and expectorant. Regardless of diseases and syndromes of cog nitive impairment can be used of addition and subtraction compatibility2. Prescription data from different data sources, classification of diseases and p ermit factors are differences. Ancient physicians pay attention to tonic, and mo dern physicians attend to combine dispel evils with tonic. The most important of treatment VaD is promoting blood circulation,followed by benefit of qi and kidney. The treatment AD is emphasized benefit of qi, spleen and kidney, foll owed by promoting blood circulation and expectorant. The tonic and expectoran t herbs are higher than others from the type and frequency in prescriptions tre atment "sputum". The herbs of enriching the blood and promoting blood circul ation TCM are higher in prescriptions treatment "stasis". The tonic herbs in pr escriptions treatment "weak" are higher. It’s consistent with pathological mecha nisms of cognitive impairment.3. Based on TCM inheritance system more intuitive reflects the cognitive impai rment of herbal rule, which avoid the limitations of personal experience, prove the data mining technology in the field of TCM prescriptions summary law pl ays an important role. The new combinations and prescriptions calculated in en tropy clustering, part of them originate from classic or common prescription an d similar prescriptions, provides reference and data support for the clinical treat ment of cognitive disorders. New combinations with rare compatibility provide useful clues for found new prescriptions and deserve further experimental studi es and clinical exploration.