Influence On Cardiopulmonary Exercise Testing Index Of Obstructive Sleep Apnea

Objectives: To assess cardiopulmonary function damage of obstructive sleep apnea hypopnea syndrome(OSAHS) patients, comprehensive contrast of the cardiopulmonary exercise testing(CPET) indexes were performed at different workloads.Methods: We selected 61 cases of OSAHS patients, which contained 8 cases of the mild OSAHS, 20 moderate OSAHS cases and 34 patients of the severe patients in mild OSAHS group, moderate and severe OSAHS group accordingly; Meanwhile, 20 cases of simple snoring as control group. Detected static lung function and Cardiopulmonary exercise testing of all the patients,recorded changes in value of related indicators.Results: 1, In the Peak Exercise stage, VO2% pred, VO2/HR% pred, BR of the OSAHS group was significantly lower than the snoring; while EQCO2 significantly higher, which was Significant correlation with AHI.2, Patients with moderate OSAHS when Peak Exercise stage VO2% pred,VO2/HR% pred, BR, EQCO2 group compared with snoring and mild OSAHS group, showing statistically significant difference(p <0.05).3, The values of VO2% pred and VO2/HR% pred at Reference stage, Anaerobic Threshold stage and Peak Exercise stages of the severe were significantly lower than those in the snoring and mild-moderate(p <0.05).4, Only at the Peak Exercise stage, BR, EQCO2 of severe and snoring-mild-moderate OSAHS group presented statistically significant.5, OSAHS group had higher systolic BP, mean arterial pressure(MAP) at Peak Exercise stage and 3-min Recovery stage, otherwise higher HR%pred at Peak Exercise stage, lower HR(%predicted) at 3-min Recovery stage than the snoring.6, Systolic BP, MAP of moderate OSAHS subjects are higher, HR%pred lower than those of mild OSAHS subjects and the control at the Peak Exercise.7, In severe OSAHS groups, There were a greater increase in systolic BP, MAP during Anaerobic Threshold, Peak Exercise and 3-min Recovery periods than other groups. HR%pred was lower at the Anaerobic Threshold and Peak Exercise, higher at 3-min Recovery period.Conclusions: 1, Compared with healthy people, OSAHS patients with heart and lung function had decreased significantly.2, Moderate OSAHS patients had heart and lung damage phenomenon in the peak stage of cardiopulmonary exercise.3, The declination of cardiopulmonary system oxygen capacity and the degree of cardiac function impairment showed statistical difference of the severe OSAHS group at lower load. By contrast, lung restricted ventilation and the degree of pulmonary ventilation disorder have difference only at higher workload. Cardiopulmonary exercise testinging has an important value in determining the severity of OSAHS patient assessment and the timing of treatment.