Expression And Clinical Significance Of E-cadherin And Vimentin In Han And Uigur In Xinjiang Area Of Colon Cancer

Objective:To evaluate the expression and clinical significance of E-cadherin and Vimentin in colon cancer and to determine the predictive value of recurrence and metastasis.Methods:Immunohistochemistry method is adopted to detect the expression of E-cadherin and Vimentin in that by surgical resection and postoperative pathological diagnosis colon cancer tissue and 5cm above normal colonic mucosa tissue from cancerous tissue for 41 cases of Uigur and 58 cases of Han.And relationship between E-cadhertin、Vimentin and clinical pathological factors was analyzed.Results:The odds tatio of poor differentiation,lymph node metastasis,distant metastasis have difference of statistically significant in Uigur and Han patients (P<0.05).The expression of E-cadherin and Vimentin have no difference of statistically significant in the colon cancer of Han and Uigur, but have difference of statistically significant in cancer tissue and normal colon mucosa tissue(P< 0.05).The expression of E-cadherin were correlated with tumor differentiation,lymph node metastasis,distant metastasis,TNM staging and recurrence and metastasis (P<0.05).However,the expression of Vimentin were correlated with lymph node metastasis,distant metastasis,TNM staging and recurrence and metastasis (P< 0.05).There was a negatively correlated between E-cadherin and Vimentin expression (r =-0.81 P< 0.05).Conclusions:The expression of E-cadherin and Vimentin were correlated with clinical characteristics.Simultaneously detection the expression of them would have a certain clinical significance on the predictors of recurrence and metastasis.