Efficacy And Security Of Zoledronic Acid For The Treatment Of Total Hip Arthroplasty With Osteoporosis

Objective:To analyse the curative effect and security of zoledronic acid on Total hip arthroplasty with osteoporosis. Methods:a total of 148 osteoporotic patients with THA were enrolled and assigned into 2 groups from 2009 to 2010. Patients were assigned into the treatment group (n=95,meanage=68.8years) receiving Caltrate D and Calcitriol plus zoledronic acid for 36 month and the control group (n=97,meanage=68.1years)receiving Caltrate D and Calcitriol only. Bone mineral density (BMD) was measured by dual-X-ray absorptiometry(DXA) at lumbar spine and the healthy hip before pre-intervention and after 36 months intervention respectively. The rate of prosthesis loosening and prosthesis adjacent fracture were be observed and compared. Results:The BMD improved in treatment group compared with pre-intervention was significantly higher than control group(P<0.05); The prosthesis loosening and prosthesis adjacent fracture in treatment group was obviously lower than control group; It is not significantly different of incidence between the two groups (P>0.05).Conclusion:zoledronic acid could significantly improve BMD, reduce the prosthesis loosening and prosthesis adjacent fracture.