Impact Of Obesity On Short-term And Long-term Mortality Acute Coronary Syndrome:a Meta-analysis

Objective:Increased body mass index (BMI) has been established as an independentrisk factor for acute coronary syndrome(ACS). This meta-analysis aims to evaluate BMI as a factor of short-term and long-term all-cause mortality in patients with ACS. Methods:Databases including The Cochrane Library, PubMed, EMbase, CNKI, WanFang Date were searched from inception to 2014 to identify cohort on BMI and short-term(in-hospital or within 30 days) or long-term (up to 6 months) all-cause mortality for acute coronary syndrome. Two reviewers independently selected the literature according to the inclusion and exclusion criteria, extracted data, and assessed methodological quality of the include studies. Then the meta-analysis was conducted using RevMan5.3 software. Results:Twenty-seven cohort publications were identified,239636 people were included. Overweight ACS patients had lower short-term[RR=0.71, 95%CI(0.64～0.79)]and long-term[RR=0.63,95% CI(0.54～0.73)] mortality risk compared to normal weight individuals. Compared to individuals without elevated BMI levels, obesity ACS patients also had lower short-term [RR=0.61,95%CI(0.53～0.69)]and long-term[RR=0.60,95%CI(0.50～0.72)] mortality. Conclusion: This study demonstrates that the obesity paradox does exist in ACS, but it has no significant difference in short-term and long-term follow-up.