Change Of Prevalence And Prognosis Of Chronic Kidney Disease Of Uygur Adults In Moyu County Between 2007 To 2013

Objective:To investigate the change of prevalence and risk factors of chronic kidney disease (CKD) of a Uygur adults population, using two cross-sectional surveys with six-year apart, in Moyu county, Xinjiang Uygur autonomous region.Methods:A representative sample of rural Uygur adults in Moyu County was selected using a stratified, multistage sampling method in 2007, and was followed in 2013. Indicators of kidney damage were measured at both 2007 and 2013; and then incidence of CKD, which was defined by presence of albuminuria and/or decreased renal function, was calculated. The survival status of participants was also documented in 2013; then the effect of CKD on risk of mortality was estimated.Results:Among 1552 participants selected in 2007, we were able to follow 85.6% (n=1329) of them.1256 subjects (81%) with complete date were enrolled in the study. With the prevalence of CKD increased from 5.4%(95% confidence interval [CI]5.3-5.5%) in 2007 to 6.5%(95%CI6.4-6.6) in 2013, after making adjustment for age. Meanwhile, the prevalence of albuminuria was 4.5%(95%CI4.4-4.6) in 2007 and 4.9%(95%CI4.8-4.9) in 2013, with borderline P value of 0.057. The prevalence of decreased renal function was 1.44%(95%CI1.39-1.49) in 2007 and 1.94%(95%CI1.90-1.98) in 2013, and the difference was statistically significant (^2=4.2, P=0.04). The mortality was significantly higher in CKD population compared with non-CKD population, which was 13.8% and 3.1%(P<0.001), respectively. After adjusting for potential confounders, the odds ratio for mortality for CKD, reduced eGFR and isolated albuminuria was 3.9,3.5 and 3.0, respectively (95%CI1.904-7.789,0.725-16.384,1.255-7.197). Age and hypertension were independently associated with CKD in 2007 and 2013. Female and hyperuricemia were new related risk factors associated with CKD in 2013.Conclusions:The prevalence of chronic kidney disease among the same population increased with age increment. And even mildly decreased renal function and isolated albuminuria was associated with increased risk of death.