Treatment Of Port Wine Stains With Pulsed Dye Laser:a Retrospective Study Of 848 Cases In Shandong Province, China

Backgrounds:Port wine Stains is a common congenital vascular malformation. Pulsed dye laser (PDL) has been the golden standard for PWS treatment, However, the efficacy of PDL differs in different populations.Objectives:The purpose of the study is to investigate the efficacy and related factors of 595nm PDL in the treatment of PWS in Chinese patients with skin type III to IV.Material and Methods:848 cases that were treated with PDL were enrolled and analyzed in this study. An independent dermatologists evaluated these lesions according to the before and after photographs.Results:The response rate (RR) of all the 848 PWS patients was 69.9%, in which the cure rate was 6.3%. The patients treated within one year old had the highest RR (93.9%), whereas those treated after 50 years old reacted the worst (RR,25%). We analyzed the anatomical distribution of the lesion and found that the temporal region had the highest clearance (RR, 75.3%), while the extremities had the lowest clearance (RR,44.5%). Compared with the patients whose lesion size was larger than 80 cm2, the patients with small lesion size of 0-20cm2 had better clinical effect (RR,73.8% vs.53.2%). The reactions of the patients with hyperplasia lesion were worse than those with red patches (RR,36.4% vs.71.7%). And increasing treatment numbers could reach higher clearance rate (P=0.005).Conclusions:The PDL had a relatively high response rate but a low clearance rate in Chinese patients with PWS. And the earlier interventions, the better efficacy. The response of PDL was not only related to the anatomical area, but also to the lesion size, whether existing hyperplastic lesions, and the number of treatment, which was essential for the evaluation of therapeutic effect and acquisition of patients consent before treatment.