| Objective: The main purpose of this topic is under the guidance of TCM theory,through the animal experiment research kind of Chinese traditional medicine for activatingblood circulation to bleomycin to the mechanism of action of pulmonary fibrosis in rats. Toobserve the promoting blood circulation to remove blood stasis type Traditional ChineseMedicine (TCM) in the lung tissue of pulmonary fibrosis rats IL-8, TNF alpha, TGF-beta1,VEGF and abdominal aortic blood SOD and GSH in the indicators of change, the kind ofChinese traditional medicine for activating blood circulation to bleomycin to themechanism of action of pulmonary fibrosis in rats.Methods: The theoretical study: Search words to the four main database retrieval goal,retrieved1978-2013period have been reported in the clinical treatment of all animals usedin experiments and compound medicine alone, through screening, analysis, the highest infive bit of five drugs, and to elect their own representatives blood circulation class of drugsbased on Traditional Chinese Medicine research direction. Experimental study: Select SPFlevel32healthy male SD rats were randomly divided into four groups8. N groups: controlgroup; M groups: model group; Z group: blood circulation category of traditional Chinesemedicine treatment group; P Group: prednisone treatment group. Z, M, P intratrachealbleomycin group dropped5mg/ml solution (5mg/kg); After modeling is completed, Mgroup of normal feeding, P rats with prednisone solution (3mg/kg) daily gavage; Z groupto Salvia (crude drug2.05g/kg), Chuan Xiong (crude drug0.77g/kg) decoction orally.27consecutive days. The first28days dissecting rats, observed in lung tissue IL-8, VEGF andchanges in TNF-α, TGF-β1, abdominal aortic blood SOD, GSH indicators. Application SPSS17.0software for statistical analysis of experimental data, comparing the differencesin each group of rats indicators discussed blood circulation category of traditional Chinesemedicine for pulmonary fibrosis in rats.Results: Theoretical study: Included473effective literature eventually screen21classes, Chinese traditional medicine,233, a total of6487frequency. Including gas, Yintonic medicine, promoting blood circulation to remove blood stasis drugs, heat, phlegmcough antiasthmatic5top five categories of drugs. Selected on the basis of researchdirection, promoting blood circulation to remove blood stasis drugs as the research object,salvia miltiorrhiza and rhizoma chuanxiong in promoting blood circulation to removeblood stasis type of the use of Traditional Chinese Medicine (TCM) in the first place, sochoose drug represented by salvia miltiorrhiza, rhizoma ligustici wallichii, study classChinese medicine for activating blood circulation to the mechanism of action of pulmonaryfibrosis in rats. Experimental study: invigorate the medicine treatment group, prednisonetreatment group compared with model group the indicators are an improving trend, andinvigorate the circulation of medicine treatment group indicators better than prednisonegroup, that kind of Chinese traditional medicine for activating blood circulation andprednisone has curative effect of pulmonary fibrosis in rats, and promoting bloodcirculation to remove blood stasis type of the curative effect of TCM for pulmonaryfibrosis in rats is superior to prednisone group.Conclusion:"Blood stasis" is an important pathological factors in the process ofdevelopment, through the experimental study and application of promoting bloodcirculation to remove blood stasis type of traditional Chinese medicine treatment ofpulmonary fibrosis in rats, from pathological analysis, gene level and so on all have a goodimprovement, that kind of Chinese traditional medicine for activating blood circulation hasexact curative effect on pulmonary fibrosis in rats, which provides new thinking forclinical treatment of pulmonary fibrosis and targets. |
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