Study On Shenqifuzheng Injection Application In Heart Disease Clinical Condition And Safety Evaluation

Objective:By investigating shenqifuzheng injection in the clinical usage ofcardioascular disease,summarizes the problems existing in the clinical use incardiovascular disease and put forward the corresponding method of monitoring andinvestigation is influential factors ginseng and astragalus injection on blood pressure, toimprove its rationality, security in cardiovascular disease in clinical use.Methods:Adopt the method of tracking the current cases, clinical factors in121casesof the use of ginseng and astragalus injection in patients with cardiovascular disease as theresearch object, the basic condition of the item by item records medication, clinicaldiagnosis, usage, dosage, course of treatment, combination and adverse reactions, etc.,after completion of treatment (maximum8weeks) to evaluate the clinical application ofrationality, at the same time monitoring factors in the use of ginseng and astragalusinjection treatment of cardiovascular diseases (excluding hypertension) in patients withnormal blood pressure, and compare the clinical symptoms improved after treatment inpatients with high blood pressure, antihypertensive effectiveness, success rate and bloodpressure, blood pressure standard time and so on curative effect.Results:1.Shenqifuzheng injection mainly used in the treatment of coronaryatherosclerosis diseases such as heart disease, high blood pressurt; Card type is mainly qideficiency blood stasis.2.This study use time is1-7days more, should according topatients’ constitution, disease in clinical situations into account.3.Drug combination: drugcombination type many, many such as antibiotics, myocardial polarization fluid,antihypertensive drugs.4.Heart disease in the elderly, due to the elderly, at the same timemore merger other system diseases.5.The blood pressure effects: Infusion fall before theblood pressure of hypertension patients after the infusion, the two significant differences,Shenqifuzheng injection can enhance the effect of antihypertensive drug efficacy, and the antihypertensive effect of systolic blood pressure is higher than the diastolic pressure effect;Shenqifuzheng injection can increase blood pressure in patients with normal diastolic bloodpressure.6.Adeverse reaction rate of Shenqifuzheng injection was1.82%.7.The inciidenceof adverse reactions of different age groups was no significant difference.8.The incidenceof adverse reactions of different sex groups was no significant difference.9.Adversereaction tates of different diseases was significantly,4cases of adverse reaction cases ofcoronary atheroscierotic heart disease (angina) in2cases, accouted for50.00%, the othertwo cases of high blood pressure, cardiac arrhythmia (atrial fibrillation).10.Incidence ofadverse reactions in different syndrome types have significant differences, the highestincidence of adverse reactions of debility blood stasis syndrome.11.Have allergy historyincidence of adverse reactions was significantly higher in patients with no histoty ofallergies to patients. Patients with a histoty of allergies the incidence of adverse reationswas6.52%, no allergy patients the incidence of adverse reations was0.57%.12.Adversereations are mild, severe complications and deaths.13.The clincial manifestations of theadverse reations have ithchy skin and the pain of the blood vessels.14.Time more than4-30min after the start of the infusion, the duration between an hour more.Conclusion:1.Shenqifuzheng injeaction has been widely applied in heart, can be usedfor chronic diseases such as heart failure, angina pectoris, card belongs to qi deficiency andblood stasis, use1-7days, suitable condition and decide, this drug can increasehypotensive effect, antihypertensive effect; In patients with normal blood pressure has theeffect of elevated diastolic blood pressure, mechanisms need to be further discussed.2.Shenqifuzheng injeation low incidence of adverse reactions, degree of light, will notresult in a patient’s blood system, kidney function, such as damage, always has a history ofdrug allergy patients should be careful, when use should be strictly grasp the indications,using reference manual specification, in order to reduce the occurrence of adversereactions.