TMPP Phosphace Osmotic Pump Tablets Used GastroPlusTM Software To Simulate And Optimize Prescription

Tetramethylpyrazine phosphate osmotic pump tablets has characteristics like a short half-life, rapidly absorbed, widely distributed and mainly rapid elimination in the liver metabolism, so the current route of administration or administration methods bring patients and healthcare professionals of great inconvenience and suffering, so the researchers developed a long-term commitment to researchers long-term commitment to the development of controlled release formulations of Tetramethylpyrazine phosphate osmotic pump tablets. Shen Teng laboratory developed the tetramethylpyrazine phosphate osmotic pump tablets prescription. The purpose of this paper is to use GastroPlusTM software to verify and optimize the prescription.GastroPlusTM is a kind of simulation software which based on the development of ACAT model used in oral drug absorption prediction, and helps the prescription optimization of controlled release formulations a lot. The software can simulate the in vivo behaviors of different drugs and preparations by various routes of administration, and predict absorption, pharmacokinetics and pharmacodynamics of the drug in animals and humans, fasting and eating two states, This article hopes to use GastroPlusTM software make simulation for in vivo absorption of Tetramethylpyrazine phosphate osmotic pump tablets osmotic pump tablets. Study the effects of different release medium, speed, and release testing methods for in vivo absorption of Tetramethylpyrazine phosphate osmotic pump tablets, Thus we can verify on TMPP osmotic pump tablets prescription and made optimization methods, studied whether the osmotic pump tablets have in vivo correlation. We also studied whether the simulation software GastroPlusTM can be used to predict transdermal patch.