An Experimental Study Of Pathophysiological Basis Of Using Left Superior Adrenal Vein To Perform Portosystemic Shunt

Object: Preliminarily to discuss the prehepatic portal hypertension(PPH) of young rat in model,afterhad copied model the diameter of the left adrenal had enlarged, the portal pressure (PP) with left ardentvein no correlation.No effect renal function and adrenal function by ligation the left adrenal vein.To provedtheory pursuant of diagnosis and choiced surgical method with PPH childrenMethod: Eighty male young Wistar (male40and female40) rats were divided into four groups: ShamOperation groups(SO,n=20), Partial Portal Vein Ligation groups(PPVL,n=20), Left Renal Vein Ligationgroup(LRVL,n=20), Partial Portal Vein Ligation combine Left Renal Vein Ligation group (PPVL+LRVL,n=20).By partial ligation of the portal vein and(or) ligation left adrenal vein to builded model ofPPH.At postoperative (postop) six weeks to measured the portal pressure, portal phlebography, pathologyet al and observated portal, around the formation of collateral circulation, changed on diameter of the leftrenal vein, effects on renal and adrenal function after ligation of the left adrenal vein.Results:1.SO group was not formed portal hypertension and portal venography of collateralcirculation at postoperative six weeks, Which PPVL, PPVL+LRVL group portal phlebography of hepatichilum has visibled collateral circulation of intrahepatic.2.PPVL group had compared with the SO group at postoperative six weeks, the portal pressure hadincreased (15.05±1.55cmH2O)(p <0.05),the left adrenal vein diameter (0.21±0.02mm)(p <0.05) hadenlarged.3.Renal function (Scr, BUN) and adrenal function（ALD, COR, ACTH）of the three model groupspresented no difference compared with the control group（p>0.05）.Conclusion:1.The diameter of the left renal vein had enlarged of young Wistar of PPVL group,provided conditions of through the left adrenal vein to portosystemic shunt.2.There was no effect on renal function and adrenal function after the ligation of left adrenal vein. Noobvious pathological changed with kidney and adrenal gland.3.Left adrenal vein is an important collateral circulation.4.The portal pressure (PP) with left ardent vein no correlation.