The Effects Of Non-Invasive Ventilator In Treatment Of Acute Exacerbation Of Chronic Obstructive Pulmonary Disease

Objective:To access the value of non-invasive ventilator in acute chronic obstructive pulmonary disease patients with respiratory muscle fatigue, but not respiratory failure. Methods:70cases of AECOPD patients with respiratory muscle fatigue were divided into two groups randomly: control group and Non-invasive positive pressure ventilation breathing machine (NIPPV) treatment group. Conventional therapy was given to the control group. NIPPV was added to the NIPPV treatment group, except from common therapy. The aim is to evaluate the clinical symptoms, signs, blood gas analysis and pulmonary function indexs of patients in both groups before and after one week treatment. Results:After the treatment, clinical symptoms and signs scores in both groups showed a downward tread(P<0.05), while the NIPPV treatment group decreased more significantly(P<0.05). The time of improved symptom in the NIPPV treatment group showed shorter than the control group(P<0.05). After treatment, pH, PaO2and SaO2in both groups increased while PaCO2decreased more significantly (P<0.05). PaO2and PaCO2in NIPPV treatment group improved more obviously (PO.05), while pH and SaO2had no significant differences(JP>0.05). After treatment, FEV1, FVC, FEV1actual/estimated and FEV1/FVC all increased (PO.05), while FEV1actual/estimated and FEV1/FVC increased more significant in NIPPV treatment group (P<0.05). Conclusion:In AECOPD patients with respiratory muscle fatigue, even if not accompanied with respiratory failure, early application of NIPPV treatment can improve clinical signs and symptoms, shorten the time of symptom improvement, improve ventilation and relieve respiratory muscle fatigue and prevent the occurrence of respiratory failure.