| ObjectiveTo evaluate the therapeutic effect of diet and nutrition intervention on type2diabetes mellitus (T2DM) patients with pulmonary tuberculosis(TB).Methods1. Subjects72subjects who were T2DM with TB from September2013to March2014in the Department of respiration of Zhengzhou Sixth Peoples Hospital were collected The WHO1999diagnostic criteria for diabetes and infectious tuberculosis was taken.2. Project designThe patients were randomly divided into the experimental group and control group, each group had36cases. The conventional treatment and health education were performed in the control group, while health education and dietary intervention were performed in the experimental group. The two months intervention was taken. The data including basic situation, disease status, regular diet and habits, awareness of diet requirements and related clinical/laboratory indexes before and after intervention were respectively recorded by using the questionnaire form.The fast blood glucose(FBG) and blood glucose2hours after meal were determined by using glucose oxidase-peroxidase method.To find if the pleural effusion and lesions were absorbed after intervention. The number of positive sputum cases before and two months after the intervention were tested and recorded.3. Statistical Analysis The SPSS12.0was used for statistical analysis.The mean±standard deviation (x±s) was used to describe the continue variables when the data were normal distribution, t test was used to compare the differences between the two groups, otherwise, using the median and quartile range (QR)description. Rank sum test was used for comparison between groups. Qualitative data were expressed by a percentage; the chi-square test was used to compare the difference between the groups, α=0.05.Results:1. Characteristics of subjectsThere was no difference between the control and experimental groups in sex, age, course of disease, height, weight, body mass index distribution (all P>0.05), the percentage of smoker between them had statistically significant difference (P=0.032).2. Blood glucoseBefore intervention, the FBG and blood glucose2hours after meal had no statistical differences in the two groups (P=0.665, P=0.390). The FBG and postprandial blood glucose in intervention group after the intervention were (6.371.22)(mmol/L) and (11.56±1.69)(mmol/L) respectively, which were significantly lower than those in the control group (9.12±1.21(mmol/L),14.20±1.32(mmol/L)), and they all had statistical differences (both P<0.01).3. Pleural effusion absorption and lesions change between the two groupsThe proportion of patients in the intervention group whose pleural effusion reduced significantly or even disappeared was higher than that of the control group (x2=10.797, P=0.002); while the proportion of patients in the intervention group whose tuberculosis reduced or closed higher than that of the control group, but there was no statistical difference (x2=1.532, P=0.216).4. Comparison of the sputum turning negative rate between two groupsThe difference of sputum positive proportion between two groups had no statistical difference (x2=2.057, P=0.151) before intervention. And after the treatment, the proportion of sputum positive cases in the intervention group was significantly lower than that of control group (x2=4.600, P=0.032),5. The changes of glycosylated hemoglobin in two groups before and after interventionAfter treatment, glycosylated hemoglobin in intervention group was significantly lower than that in control group (t=6.193, P<0.01);the glycosylated hemoglobin in both groups were significantly lower than that before treatment (P<0.01, P=0.002).6. The medical expenses in intervention group significantly decreased compared with control group(P<0.01). The hospitalization days in the intervention group was significantly less than that of the control group.ConclusionsNutrition dietary intervention and guidance can maintain glycemic stability in T2DM patients with pulmonary tuberculosis, promote calcification healing, improve clinical symptom and decrease hospitalization days. |
PDF Full Text Request