| Diabetic peripheral neuropathy，DPN for short, is one of the mostcommon chronic complications, has various clinical manifestations. Theprocess of neuropathy is concealing and gradual and is usually not inaccordance with the clinical symptoms. As the main reason for traumaticamputation, the pathogenesis of diabetic peripheral neuropathy is notclear yet. It is generally considered that diabetic peripheral neuropathy isrelated with metabolic abnormalities, micro-vascular lesion, oxidativestress, lack of neurotrophic factors and the immune system, and oxidativestress is one part of the mechanism of DPN hypothesis such as AGEs,polyol metabolism, PKC activation and microvascular lesion. Uric acid,as the ultimate product of purine metabolism, is the most sufficientnatural antioxidants in human body. What’s more, the oxidative stress isinvolved in the whole process of diabetic peripheral neuropathy. It can beconcluded from the above that a high level of blood uric acid facilitatesnerve protection and further reduce the occurrence of DPN to some extent.However, the researches abroad prove that the uric acid level of DPNpatients is significantly higher than that of non-DPN patients, and suchconclusion is not in line with the speculation at home. However, there aresome specific questions need to be figured out. Whether a positivecorrelation exists between the uric acid level and the incident rate of DPN?What are the incident rates of DPN considering different level of blooduric acid? Is there an optimum uric acid level that prevents the occurrence of DPN? What is the relationship between blood uric acid and othermetabolic factors? So far, few researches focusing on the above questionshave been conducted. Thus this paper analyzes the1905cases of type2diabetic patients and studies the correlation between the blood uric acidlevel and DPN as well as other metabolic factors.Research purpose:The paper aims to provide theoretical basis for the clinical treatmentby studying the correlation between the level of blood uric acid and DPNof type2diabetic patients.Research method:The study chooses1905patients which have been confirmed as type2diabetes patients in endocrinology department, Second Branch of NO.1Hospital of Jilin University from January2011to January2014.The basicinformation of those patients such as sex, age and menopause of femalepatients as well as the statistical parameters such as uric acid, blood lipids,HbA1c and fasting blood glucose have been recorded in the database forthe research. Screening has been conducted among all the patients tojudge whether they have DPN. Firstly, the1905cases are classified intotwo groups, the patients with DPN and the patients without DPN, and acomparison will be made in terms of incident rate of hyperuricemia andblood uric acid level. Then the patients will be divided into differentgroups according to the incident rate of DPN and the correlation betweenblood uric acid level and DPN will be analyzed. Besides, the study objectwill be classified into two groups, one group with hyperuricemia andanother group with normal level of uric acid, and the relationship betweenblood uric acid，blood lipids and fasting blood glucose. As for thestatistical method, SPSS17.0software will be used to analyze the data andit makes sense from the perspective of statistics when the value of P is less than0.05.Research result:1. The incident rate of HUA of DPN patients is higher than that ofNon-DPN patients; the average level of blood uric acid of DPN patients ishigher than that of those without DPN.2. For the premenopausal female patients, the incident rate of DPN isthe lowest when the blood uric acid is between240umol/L and259umol/L; As for male and postmenopausal patients, the occurrence rateof DPN is the lowest when the blood uric acid is between300umol/L and359umol/L3. The level of cereal third transaminase, triglyceride, low densitylipoprotein cholesterol (HDL-C) and fasting blood glucose inhyperuricemia group are higher than that of the group in which the blooduric acid is normal, and the comparison between the two groups ismeaningful from the perspective of statistics. However, the level of thecholesterol, high-density lipoprotein cholesterol (HDL-C) andglycosylated hemoglobin shows no differences between the two groups.Conclusion:The uric acid is a negative factor for the diabetic peripheralneuropathy of type2diabetes patients. The incident rate of HUA of DPNpatients is higher than that of Non-DPN patients; the average level ofblood uric acid of DPN patients is higher than that of those without DPN.For the patients who both have hyperuricemia as well as DPN, theincident rate of DPN is the lowest when the blood uric acid is between240umol/L and259umol/L for premenopausal female patients, and whenthe uric acid is between300umol/L and359umol/L for male andpostmenopausal patients. The uric acid is closely related with cereal thirdtransaminase, triglyceride, low density lipoprotein cholesterol (HDL-C) and blood sugar, which all contribute to the type2diabetic chroniccomplications. |
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