Analysis On The Clinical Characteristics And Prognosis Of Pulmonary Neuroendocrine Tumors

Objective: Since Pulmonary neuroendocrine tumors(NET) are rare andheterogeneous diseases, their prognosis and long-term survival are not well known.This article retrospectively review the clinical characteristics and analyze theprognostic factors of Chinense patients with pulmonary neuroendocrine tumors.Materials and methods: The clinical date of176patients with pulmionaryneuroendocrine tumors in Chinese PLA General Hospital from Mar.,2000toDec.,2012were retrospectively analyzed.The parameters were evaluated by univariateand multivariate analysis, including the gender,age,smoking history,familyhistory,TNM staging,localization(central or peripheral),tumor size, nodal status,histol-ogical subtype and treatment(operation or non-operation).Results：There were23patients with TC(13.1%),41with AC(23.3%),10patientswith LCNEC(5.7%) and102with SCLC(57.9%).The median follow-up time was64.5months for AC,38months for LCNEC and27months for SCLC.The typical carcinoidcensored data was18(more than50%of the patients),so the median follow-up timewas not obtained,and actuarial5-year survival for TC,AC,LCNEC and SCLC were75.1%,51.7%,,26.7%and38.8%,respectively.COX univariate analysis revealed thatthe age (p=0.001),histological subtype(p=0.005), nodal status(p=0.000),treatment(p=0.000) and TNM staging(p=0.000) were the prognostic factors of the patients withpulmonary neuroendocrine tumors,whereas its multivariate analysis showed that onlythe age(p=0.001), TNM staging(p=0.002) and treatment(p=0.000) were theindependent prognostic factors.Conclusions:Radical surgery remains the treatment of choice, and is the onlycurative option for patients with pulmonary neuroendocrine tumors.The age,TNMstaging and treatment are confirmed to be the independent prognostic factors in themultivariable models for pulmonary neuroendocrine tumors.