Pharmacokinetics Of Gastrodin、Rhynchophylline From Tiangou Jiangya Capsule In Rats

Objective:To study the influence on the pharmacokinetics of gastrodin in rats when the rats are given different doses of Tiangou Jiangya Capsule through intragastric administration and to study the influence of compound compatibility on pharmacokinet-ics of gastrodin and rhynchophylline in rats.Methods:To determine the content of gastrodin and rhynchophylline in the plasma of rats through HPLC. The plasma concentration-time curves in every medication administration team are fitted by3P97Pharmacokinetic software, then pharmacokinetic parameters between every groups are statistical analyzed by SPSS16.0. Results:After oral administration of gastrodin.gastro-din in rat was fitted to the one-compartment model, Cmax and AUC of Tiangou Jiangya capsule were in direct proportion to intragastric administration dosages, and t1/2(Ka)has nothing to do with intragastric administration dosages. There are some differences between the pharmacokinetic parameters of isodose gastrodin in Tiangou Jiangya capsule and Gastrodiae rhizoma extract, there are the significant decrease of Cmax、Ke and significant increase of t1/2Ke)、V/F(C) and no significant difference of AUC、T(peak) in compound Tiangou Jiangya capsule. After oral administration of rhynchophylline, rhynchophylline in rat was fitted to the one-compartment model, there are the significant decrease of Ka、Cmax、Ke, significant increase of t1/2(Ka)、T(peak)、t1/2(Ke), and no significant difference of AUC、V/F(C) in compound Tiangou Jiangya capsule. Conclusion:After oral gastrodin, it was fitted first-order rate in vivo transafter process,and absorbed quickly,did not accumulate in body. Compound compatibility can delay the absorbtion of gastrodin in vivo, promote the distribution in vivo and prolong the resident time in vivo but bioavailability of gastrodin is not significantly affected, it still can delay the absorbtion of rhynchophylline in vivo and prolong the resident time in vivo, but bioavailability and biodistribution of rhynchophylline is not significantly affected.