| Objective: To study whether the intervention in the number of circulating tumor cells (CTCs) can improvethe objective response rate (ORR), disease control rates (DCR), progression-free survival (PFS) and overallsurvival (OS) as well as the intervention effects on subjects’ quality of life (KPS) of small cell lung cancerpatients through clinical trials. Methods: A parallel control trial was conducted mainly in The First HospitalAffiliated to Shihezi University and People’s Hospital of Shihezi City. Take small cell lung cancer patientsas the research object. A total of45patients suffering from SCLC were included,26cases treated withchemoprophylaxis based on CTCs-monitor result were defined as the test group and the rest26casestreated with the traditional chemotherapy were defined as the control group. The short-term therapeuticeffects including objective response rate (ORR), disease control rate (DCR) and safety by KPS evaluationwere evaluated in the two groups. In the follow-up, progression-free survival (PFS) and overall survival(OS) were also observed. Results:45cases carried through the trial, in the participants’ blood samplesbefore chemotherapy, the peripheral blood CTCs positive detection rate was of81.0%, compared with20cases of control group (0%), it was statistically difference (P=0.001), the sensitivity of the detectionmethod is82%, and the specificity was100%. The ORR was18.2%and12.2%, respectively (P=0.767),and the DCR was86.4%and61.2%, respectively (P=0.034). The median time to progression in the test andcontrol groups was135days and100days with significant difference (P=0.047), while the median overallsurvival was293days and315days with significant difference (P=0.048). No significant difference in theside effects was found between the two groups. Conclusions: CTCs-based chemoprophylaxis resulted in ahigher DCR and longer PFS and OS in the patients with SCLC, and the toxicity was tolerable. |
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