Correlation Between Plasma Asymmetric Dimethy Larginine And Essentail Hypertension Of Kazakh,Uyghur And Han Nationalities In Xin Jiang

Objective:By comparing the difference of plasma Asymmetric dimethylarginine levels Kazak,Uyghurand Han patients with Essential hypertention in Xin Jiang,to explore the correlation between plasma Asy-mmetric dimethylarginine and Essential hpertention.Methods:93Kazakh cases with hypertention and81healthy Kazakh cases were picked out from theepidemiological investigation from November to December2012in Manasi Hanqiazitan country andShawan Dongwan country;87Uyghur patients with hypertention and83healthy Uyghur people who werein cardiovascular department of friendship hospital in lli XinJiang were picked out during February to June2013;and at the same time112Han patients with hypertention and110healthy Han people who did physicalexamination.were picked out from physical examination center in the first affiliated hospital of Shi hezi University.all the cases above were brought in to the research.Acccording to blood pressure, all the casesabove were divided into test groups andcontrol groups in three nationalities.Body height,weight,wai-stecircumference and hip circumference were measured.5ml venous blood was drawn in every cases,the testgroups and control group’s level of ADMA were both measured using High perform-ance chromatography（RP-HPLC） in three nationalities.meanwhile live function,renal function,bloodlipids, blood glucoseand fructosamine were measured.Results:(1) There were no obviously statistics discrepancy of clinical and laboratory data between thepatients with Essentail hypertention in three nationalities （P>0.05）, all the patients with Essentailhypertention had higher levels of plasma ADMAthan their control groups in three nationalities, the discre-pancy has statistics significace（P<0.05）; Kazakh and Uyghur patients with Essentail hypertention hadhigher levels of plasma ADMA than Han patients,the discrepancy has statistics significace(P<0.05);theKazakh patients with hyperetention had higher levels of plasma ADMA than Uyghur patients, the discre-pancy has statistics significace (P<0.05); there was a positive correlation between the plasma ADMA andblood pressure levels of the patients with essential hypertention in three nationalities (P<0.01).(3) The lev-els of plasma ADMA in Essential hypertention patients has relevance with Total cholesterol and Low de-nsity lipoprotein in both three nationalities, but the discrepancy has statistics significace,but the relevancewas not very intimate.Conclusion:(1)The levels of plasma ADMA had increased in the patients with Essential hyperten-tion,and higher than their control groups in three nationalities.The Kazakh ptients with hyperetention hadhigher levels of plasma ADMA than Uyghur patients;(2)There was a positive correlation between theplasma ADMA and blood pressure levels of the patients with essential hypertention in three nationalities;(2)The levels of plasma ADMA in Essential hypertention patients has relevance with Total cholesterol andLow density lipoprotein in both three nationalities, indicate that ADMA might be involved in the occurren-ce and development of Essential hypertension.