Clinical Research On Attention Components Of Event Related Potentials In Patients With Vascular Cognitive Impairments With No Dementia

Objective：The purpose of this paper is to analyze thechange features of CNV、 P300in patients with vascular cognitiveimpairments with no dementia and proceed the clinicalneuropsychological test, in order to find the application value of CNV、P300and neuropsychological test in attention impairment in vascularcognitive impairments with no dementia,for improving its diagnosticquality. Methods: Select70cases of2013June to2014January inLuzhou Medical College Department of internal neurology patients andhospitalized patients,divided into3groups:30patients with vascularcognitive impairment no dementia (VCIND),20patients with vasculardementia (VaD) and20normal control. All the patients pasted theHamilton depression rating scale out of depression, then completed thefollowing tasks:1,Assessment of the general cognitive functions:Mini-Mental State Examination (MMSE),Montreal cognitive assessment(MoCA);2, Neuropsychological test:①Sustained attention: ContinuousPerformance Task (CPT),②Selective attention:the Stroop Color andWord Test (Stroop test),③Divided attention:Dual task;3, ERPs:contingent negative variation (CNV) and P300；4,Compeled correlation analysis.Result:1、VCIND group, VaD group and NC group in gender,age, years of education by the difference in general data such as nostatistical significance（P>0.05）.2、VCIND group had obvious cognitivedisorder in attention,executive function, memory (P<0.05), and nocognitive disorder in linguistic function,orientation and abstract comparedwith the control group(P>0.05).VaD group had obvious cognitivedisorder in attention,executive function,memory, orientation andabstract(P<0.05), and no cognitive disorder in linguistic function(P>0.05).3、 neuropsychology attention test:①Continuous PerformanceTask (CPT):Reaction time in CPT had no significantly prolonged (P>0.05)and omission rate had increased in VCIND group compared with NCgroup(P<0.05)，Reaction time of CPT had significantly prolonged(P<0.05)and omission rate had increased(P<0.05) in VaD group compared withNC group， Reaction time of CPT had significantly prolonged(P<0.05)and omission rate had increased(P<0.05) in VCIND group compared withVaD group；②Stroop test: reaction time under conflict condition hadsignificantly prolonged(P<0.05), reaction time under neutral conditioncondition as well as stroop effect under conflict and neutral conditionshad not prolonged (P>0.05),and error rate under conflict and neutralconditions had significantly increased(P<0.05), interfered effects of errorrate under conflict and neutral conditions had not increased (P>0.05) inVCIND group compared with NC group.Reaction time, error rate and their interfered effect had obviously increased in VaD group comparedwith NC group(P<0.05). Reaction time, error rate and their interferedeffect had obviously increased in VCIND group compared with VaDgroup(P<0.05);③Dual task: VCIND group did as well as NC group inthe Dual task test (P>0.05).VaD group did worse in dual task than NCgroup(P<0.05). VaD group did worse in dual task than VCINDgroup(P<0.05).4、 ERPs:①ANOVA results indicated a significantdifference in CNV expectancy wave （EW） amplitude among threegroups (P<0.05),and NC group> VCIND group> VaD group (P<0.05).ANOVA results indicated a significant difference in CNV expectancywave（EW）areas among three groups (P<0.05),and NC group> VCINDgroup> VaD group (P<0.05). No significant differences in CNVexpectancy wave latency among three groups were observed(P>0.05).VCI patients’s CNV waveform had poor differentiation and owe rules.②Compaired P300latency and amplitude among three groups: Latencyof P300had significantly prolonged and amplitude had declined inVCIND group compared with NC group(P<0.05). Latency of P300hadsignificantly prolonged and amplitude had declinedin VaD groupcompared with NC group(P<0.05). Latency of P300had significantlyprolonged and amplitude had declinedin VCIND group compared withVaD group(P<0.05).5、 Relationship between ERPs and neuropsych-ological attention tests: Correlation analysis revealed CNV expectancy wave areas had a good correlation with CPT and Stroop test, CNVexpectancy wave latency had a good correlation with Dual task.; N2latency had a good correlation with Stroop test,P300latency andamplitude had a good correlation with CPT,Stroop test and Dualtask.Conclusions:1, VCIND patients had obvious disorders in generalassessment in attention,executive function,memory，and VaD patientshad obvious cognitive impairment in attention,executive function,memory,orientation and abstract.2,Neuropsychological attention test: VCINDpatients had predominance in sustained attention impairment completelyand selective attention impairment partly; VaD patients had general,obvious disorders in sustained attention, selective attention and dividedattention.3, The disorders characteristic of ERPs in VCIND patients:CNV expectancy wave areas and amplitude、 N2、 P3latency and P3amplitude disordered. VaD patients also had these taegets disordered andmore woese,combine P2latency disordered.4、 CNV and P300respectively correlated with CPT, Stroop test and dual task, therefore,CNV and P300can reflect different aspects and extent of damage invascular cognition impairment.