| Objective:(1)Explore preliminary construction of a clinical suitable Oncology Cases Whole-Course Management System for our hospital.(2)Collect young colorectal cancer (CRC) cases in our hospital during2006to2013with this system, try to investigate the clinical characteristics.Methods:(1)Construct a database management system through the way of system design, database creation, coding, special algorithm design, run and debug, which would achieve the desired functionality.(2) Retrospective analysis the clinical data of53cases of young (≤35years old) colorectal cancer confirmed by Liuzhou People Hospital from January2006to December2013which were collected by the Oncology Cases Whole-Course Management System, while with the random sampling of53cases of elder colorectal cancer were compared at the same period.Results:(1)We construct the Oncology Cases Whole-Course Management System successfully, which functions add, modify, delete of cases information, diagnosis, treatment, follow-up data and data query, statistics, analysis.(2) Young patients with colorectal cancer accounted for the same period in colorectal cancer cases confirmed by our hospital from January2006to December20133.1%, male cases were more than females.(3)The misdiagnosis rate of the young group is34.0%, significantly higher than control group (P<0.05).(4)The main clinical manifestations were bellyache, blood stool, bowel habits changes and varying degrees of systemic symptoms in both groups, while bellyache (67.9%), loss of appetite (39.6%) in young group were significantly higher than control group (P<0.05).(5)Rectum was the most frequent position of CRC in both groups. The young group with poorly differentiated carcinoma (including poorly differentiated adenocarcinoma and mucinous adenocarcinoma) accounted for33.9%, significantly higher than control group (P<0.05).(6)C and D of Dukes staging in young group accounted for69.8%, significantly higher than control group (P<0.01).(7) CEA, CA19-9, CA12-5, CA72-4values were associated with Dukes’stage showed a positive correlation.(7) The compliance with adjuvant chemotherapy was significantly higher than control group (P<0.01).(8) Clinical staging and treatment were important factors affecting survival of patients (P<0.001).Conclusion:(1) Through the preliminary construction and application of the Oncology Cases Whole-Course Management System we get informational management and long-term follow-up, conducive to timely understand patients’ diagnosis, treatment and survival, which can provide effective guidance and improve patients’compliance with treatment and follow-up. Accumulation of a large variety of relevant data for clinical research can help to improve the level and quality of research, together with patients’quality of life, survival and tumor control effect.(2) The system is still in the preliminary stage so that we need further improvement in its operation.(3)The rate of young colorectal cancer patients confirmed by our hospital from January2006to December2013is similar to other areas, male cases accounted more than females.(4) There are lack of specificity in young patients with colorectal cancer, which has high misdiagnosis rate, poorly differentiated, high malignancy. Most metastasis has occurred when diagnosed.(5)Tumor marker values are associated with Dukes’ stage showed a positive correlation..(6)Young cases have higher rate of chemotherapy after operation.(7) Clinical staging, differentiation and treatment are important factors affecting survival of patients.(8)It’s helpful for us to early diagnosis by improving recognition, paying attention to rectal examination, regular colonoscopy and tumor markers testing for high-risk populations. |
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