Analysis Of Risk Factors And Drug Resista-NCE Of Multidrug Resistant Of The Respiratory Acinetobacter Bauannii Infection In ICU

ObjectiveTo investigate the risk factors and drug resistance of pneumonia caused by multi-drug resistant Acinetobacter Bauman(MDRAB) in intensive care unit and provide evidence for clinical diagnosis and therapy.MethodThrough a retrospective survey of77cases of Acinetobacter buamannii cultured from sputum and fiberbronchoscope fluid which came from the patients in ICU from Dec2010to Dec2013, the related risk factors and drug resistance about antibacterials were investigated and analyzed by using the software SPSS16.0.ResultThe result of single factor analysis showed that MDR-AB infection was associated with the ICU check-in time of patients, intubation or tracheotomy, invasive mechanical ventilation, deep venous catheter placement, times of bronchoscopy therapy, coma, and usage of β lactam-lactamase inhibitor (p<0.05).Logistic multivariate regression analysis showed that the ICU check-in time of patients, intubation or tracheotomy, invasive mechanical ventilation, deep venous catheter placement, times of bronchoscopy therapy, coma, and usage of β lactam-lactamase inhibitor were the independent risk factors. The result of the drug resistance indicated that the antimicrobial drugs rate of MDB-AB is more than70%and maintains a certain sensitivity to the cefoperazone/sulbactam (sulperzon).ConclusionIn order to prevent and control the infection of MDRAB, Invasive operation and Mechanical ventilation time for the ICU patients should be decreased and the antimicrobial drugs should be used rationally.Because MDRAB is resistant to most of the clinical antimicrobial drugs, so the antimicrobial drugs should be chosen according to the drug sensitivity results. Imipenem, cefoperazone/sulbactam or drugs containing sulbactam can be used in the treatment of MDRAB infection.