Clinical Research Of Integrative Medicine Treatment Of Polycystic Ovary Syndrome Accompanied By Obesity And Hyperinsulinemia

Objective:to observe and study the treatment of integrative medicine of polycystic ovary syndrome (PCOS) accompanied by obesity and hyperinsulinemia, and evaluate its effectiveness and safety, preliminary study the etiology, pathogenesis and treatment of PCOS, in order to provide an objective basis for clinical use.Method:select43cases of PCOS which met the inclusion criteria, and fifteen weeks treatment with prescription of strengthening the spleen and reducing phlegm, metformin and lifestyle intervention, observe the improvement of the indicators with the method of before and after self-control study. observe the improvement of menstruation, pregnancy, acne, hirsutism, etc. after treatment, measure the serum sex hormones: Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), Testosterone (T), Free Testosterone (FT) and LH/FSH ratio etc. measure oral glucose tolerance test (OGTT) and insulin release test, and HOMA-IR values, observe the insulin resistance and blood sugar after treatment, measure weight and height, then calculate BMI values, observe the improvement of obesity after treatment, observe the adverse reactions what may occur during medication and the compliance of patients. All data will be statistically analyzed.Results:(1)Tradational Chinese Medicine (TCM) symptoms:after treatment, the symptoms are significantly improved, the total effective rate is90.7%; the integration of TCM primary and secondary symptoms are significantly reduced, total score before and after treatment are significantly different(P<0.05).(2)the sex hormone level: after treatment, T、FT、LH and LH/FSH reduce, with significant difference (P<0.05), FSH increases with significant difference (P<0.01).(3) insulin resistance:FINS, lh-INS、2h-INS、3h-INS and HOMA-IR significantly reduced(P<0.05), but HOMA-IR not to the normal. And no obvious change in FPG(P>0.05).(4) the obesity:Body Mass Index (BMI) significantly reduced(P<0.01), in view of weight loss, the total effective rate is97.7%,(5) B-mode ultrasound in gynecology:after treatment, PCO symptoms in patients with unilateral or bilateral eases is significant difference (P<0.01), but its integration not to the normal.(6)Pregnancy:follow-up study20people who have fertility requirements, there were7people of pregnancy, among which4people were confined, the pregnancy rate was35%.(7) adverse reactions:During treatment,2patients have a mild diarrhea, incidence of adverse reactions is4.65%.Conclusion:the treatment of Integrative Medicine can obviously improve the clinical symptoms of PCOS with obesity and hyperinsulinemia of TCM syndromes is spleen deficient phlegm dampness type, improve the levels of sex hormones and insulin resistance, make weight loss, cure performance of polycystic ovary. The treatment is safe and effective, and deserves further study.