Analysis Of Nasal And Bronchial Inflammatory Characteristics In Patients With Moderate/severe Persistent Allergic Rhinitis

Abstract:Objective To analyse nasal and bronchial inflammatory characteristics in patients with moderate/severe persistent allergic rhinitis.Methods162normal,80patients with moderate/severe persistent AR participated the nasal and bronchial provocation test, nasal lavage and induced sputum.Results1. The baseline pulmonary function of AR and normal group were no differences (p>0.05);2. The positive rate of nasal provocation test in AR group was75.2%(76/101), which was statistically higher than the control group42.5%(34/80),x2=20.081,p=0.000;3. The positive rate of bronchial provocation test in AR group was14.9%(15/101), which was statistically higher than the control group(2.5%,2/80), χ2＝8.003, p<0.05;4. The number of upper airway eosinophils in AR group (22.09±85.3) was statistically higher than the control group (0.41±1.27), t=-10.469, p<0.01;5. The eosinophils of induced sputum in AR group (11.02±18.22) was significantly higher than the normal group, which was1.62±2.88(t=-5.648, p<0.01);6. The eosinophil level of nasal lavage was related to the sputum induction in AR group (r=0.31,p<0.01). Conclusion 1. The baseline pulmonary function of AR and normal group were no differences;2. AR group showed significantly higher level of nasal and bronchial hyperresponsiveness;3. AR group existed significantly higher eosinophils level of nasal and lower airway than the control group;4. Higher EOS level and hyperresponsiveness of nasal and lower airway were the inflammatory characteristic of AR;5. The inflammation of nasal and lower airway correlated in AR patients.6. AR patients were advised to examine lower airway inflammatory status, and abnormal ones should intervene lower airway as soon as early.