Meta-analysis Of Related Risk Factors Of Hypertensive Disorders Complicating Pregnancy

Objective: Meta-analysis is used to evaluate the incidence of hypertensivedisorders complicating pregnancy common clinical risk factors and theirassociated main strength, which mainly including:(1) Maternal age≥40years old;(2) First check BMI≥35㎏/㎡;(3) History of preeclampsia;(4) Family historyof hypertension;(5) Chronic hypertension;(6) Nulliparous;(7) Nutritionaldeficiencies;(8) Diabetes;(9) Education;(10) Psychosocial stress.Methods: Pubmed, Medline, Embase, SciFinder, Cochrane, Springer,CNKI, VIP were searched for relevant literatures in English and Chinesewhich were published during2000.01～2015.01.The type of literatures arecase-control study or cohort studies. We evaluate all the collected articles withprinciples and methods of systematic evaluation introduced by the Cochranecollaboration. Meta-analysis is used to being included in a systematic reviewof the research literature analysis,with odds ratio (OR) as the effect of thevalue of count data factors, OR﹑95%confidence interval(CI) representingeach effect size range range.There are10factors of the most commonclinical extracted:①Maternal age≥40years old;②First check BMI≥35㎏/㎡;③History of preeclampsia;④Family history of hypertension;⑤Chronic hypertension;⑥Nulliparous;⑦Nutritional deficiencies;⑧Diabetes;⑨Education;⑩Psychosocial stress. The valuable data information will beextracted into the test data and Rev Man5.3software were used for statisticalanalysis.Results: The final included20case-control literature, among them haveChinese literature7Papers and English literature13Papers. The result for Meta-analysis:1.Maternal age≥40years old: the combined effect size OR was1.82,95%CI（1.47,2.26）,P＜0.001，the difference was statistically significant.2.First check BMI≥35㎏/㎡:the combined effect size OR was2.97,95%CI (2.69,3.27), P＜0.001，the difference was statistically significant.3.History of preeclampsia: the combined effect size OR was9.04,95%CI（6.87,11.91）, P＜0.001，the difference was statistically significant.4.Family history of hypertension: the combined effect size OR was5.06,95%CI (4.27,6.00), P＜0.001，the difference was statistically significant.5.Chronic hypertension: the combined effect size OR was5.09,95%CI(3.87,6.69),P＜0.001，the difference was statistically significant.6.Nulliparous: the combined effect size OR was1.54,95%C（I1.37,1.72）,P＜0.001，the difference was statistically significant.7.Diabetes: the combined effect size OR was2.70,95%CI（1.88,3.89）,P＜0.001，the difference was statistically significant.8.Psychosocial stress: the combined effect size OR was3.20,95%CI（2.63,3.90），P＜0.001，the difference was statistically significant.9.Nutritional deficiencies: the combined effect size OR was3.24,95%CI（2.49,4.22）,P＜0.001，the difference was statistically significant.10.Education: the combined effect size OR was0.58,95%CI（0.44,0.76）,P＜0.001，the difference was statistically significant.Conclusion: The etiology and pathogenesis of hypertensive disorderscomplicating pregnancy are still unknown. In this study, the major riskfactors of HDCP for Meta-analysis: Maternal age≥40years old; Firstcheck BMI≥35㎏/㎡; History of preeclampsia; Family history of hyperten-sion;Chronic hypertension; Nulliparous; Nutritional deficiencies; Diabetes; Psychosocial stress are all the major risk factors for HDCP, contact stre-ngth from strong to weak was: History of preeclampsia、Chronic hyperte-nsion、Family history of hypertension、Nutritional deficiencies、Psychoso-cial stress、First check BMI≥35㎏/㎡、Diabetes、Maternal age≥40yearsold、Nulliparous, high level of education of pregnant women is protectivefactor for HDCP. The above conclusions can be applied guide the perin-atal health care and thus prevent or delay the occurrence of the diseaseand development.