Effect Of Ketorolac Tromethamine Being Used On Patients Who Undergo Radical Resection Of Rectal Carcinoma Along With Sufentanil

Objective:To observe the safety and the effect of ketorolac tromethamine alongwith sufentanil as postoperative patient-controlled intravenous analgesia,which isused by the patients who undergo a radical resection of rectal carcinoma.To find themost appropriate mixture ratio of the two medicines.Method:Select80patients who undergo a radical resection of rectal carcinoma.The patients match the following measures:ASA I-II,44-64years old,weigh50kg-80kg.The patients are divided into four groups randomly,and each group contains20cases.All patients undergo a general anesthesia,but use different configuring method ofPCIA after extubation.Group A:sufentanil1.0μg/kg,ketorolac tromethamine3.0mg/kg,ramosetron0.6mg;Group B:sufentanil1.5μg/kg,ketorolac tromethamine3.0mg/kg,ramosetron0.6mg;Group C:sufentanil2.0μg/kg,ketorolac tromethamine3.0mg/kg,ramosetron0.6mg,Group D:sufentanil2.5μg/kg,ramosetron0.6mg.Recordthe blood pressure(BP),heart rate(HR),respiratory rate(RR),pulse oxygensaturation(SpO2),and side effects,such as nausea,vomiting,respiratoryinhibition,bleeding at the following moments: instantly (T0),1h(T1),2h(T2),4h(T3),8h(T4),12h(T5),24h(T6),36h(T7),48h(T8) after the operation.Record the intensity ofpain using the VAS,the intensity of sedation using Ramsay.Count the numbers ofpressing.Results:(1) Blood pressure(BP) and heart rate(HR):T1-T6,patients in Group A have higherBP and HR than T0(P<0.05).Patients in Group B,C and D have higher BP and HR,butthere’s no significant difference at T1and T2(P>0.05).There’s no difference amongfour groups at T0,T7and T8,T1-T6BP and HR of Group A are higher than othergroups(P<0.05).There’s no difference among the BP and HR of Group B,C andD(P>0.05).(2) Respiratory rate(RR) and pulse oxygen saturation(SpO2):there is no difference at these moments and different groups(P>0.05).(3) Intensity of pain:the scores at T1-T6are higher than the score at T0in GroupA(P<0.05);the scores at T1and T2are higher than the scores at T0in Group B,C andD,but there’s no statistical significance(P>0.05),the scores at T3-T8are lower andlower;there’s no statistical significance at T0and T8among four groups(P>0.05),thescores at T1-T6of Group A are higher than other groups(P<0.05),there’s no differenceamong the scores at T7,T8of all patients,there’s no statistical difference among thescores at T0-T8of Group B,C and D(P>0.05).(4) Intensity of sedation:the scores at T1-T6of Group A decreasedsignificantly(P<0.05).The scores of Group C and D at T2,T3and T4are higher thanT0(P<0.05).The scores at T3and T4of Group C and D are higher than the scores ofGroup A and B(P<0.05),there’s no difference among the four groups at othermoments.(5) Incidence of side effects:incidences of nausea and drowsiness are higher inGroup D than Group A,B and C(P<0.05). Vomiting, respiratory inhibition andbleeding don’t happen to all patients.(6) Times of pressing:the pressing of Group A are almost during T1-T6,thepressing of Group B,C and D are almost during T1and T2;there’s no statisticaldifference among Group B,C and D at all the times.The times of Group A at T1-T7aremore than other three groups(P<0.05).Conclusion:using a PCIA with ketorolac tromethamine3.0mg/kg,sufentanil1.5μg/kg and ramosetron0.6mg after radical resection of rectal carcinomacan can reachthe best analgesia effect with least side effects.