Analysis Of Clinical Characteristics Of Surgical Patients With Crohn’s Disease

Objective:To investigate the clinical charcateristics of surgical patients with Crohn’s disease(CD).Methods:Clinical and laboratory data of nutritional condition disease activity、 coagulation function of90surgical patients with CD (surgical group) and191non-surgical patients with CD (non-surgical group) was recorded and compared between two groups.The Montreal classification standard was included.Results:For the age of diagnosis (below16y, between17and40y, above40y) and location of disease(ileal, colonic, ileocolonic, isolated upper disease),the surgical group didn’t reach significantly statistical differences when compared with non-surgical group (P>0.05).The proportions of disease behavior stricture and penetration of surgical group was significantly higher than non-surgical group (P<0.05), Further analysis showed that surgical rate of penetration behavior was significantly higher than stricture behavior.2male surgical patients with CD developed venous thromboembolic postoperatively. Gender stratification analysis showed that body mass index (BMI) erythrocyte sedimentation rate (ESR)、albumin (ALB)、prothrombin time (PT) and activated partial thromboplastin time (APTT) was similar in surgical male patients and non-surgical male patients (P>0.05), but C-reactive protein (CRP)、platelet (PLT) and fibrinogen (FIB) of surgical male patients was significantly higher than non-surgical male patients preoperatively (P<0.05), and hemoglobin (Hb) of surgical male patients was significantly lower than non-surgical male patients preoperatively (P <0.05). BMI、ALB、Hb、CRP、PLT、FIB、PT and APTT of surgical female patients were not significantly different as compared to that in the non-surgical female patients preoperatively(P>0.05), but ESR of surgical female patients was significantly higher as compared to that in the non-surgical female patients preoperatively (P>0.05)Conclusions:Crohn’s disease patients with penetrating or strictured behavior will probably experience surgery and patients with penetrating behavior are more likely to experience surgery than those with strictured behavior. Anemia、elevated C-reactive protein and blood hypercoagulation are obvious in male surgical patients preoperatively, which may also be related to venous thromboembolic postoperatively.