The Influence Of Combined Therapy Of Atorvastatin And Aspirin On Carotid Plaques And Recurrence Rate In Patients With Cerebral Infarction

Objective:To evaluate the influence of combined therapy of atorvastatin and aspirin on carotid plaques in patients with cerebral infarction and the recurrence of cerebral infarction.Methods:70cerebral infarction patients with carotid plaque were randomly divided into two groups with each group35cases. Carotid CT angiography was checked before treatment and after12months of treatment. The patients in treatment group received combined therapy of atorvastatin and aspirin enteric-coated tablets, while patients in the control group took aspirin enteric coated tablet only. The effects of atorvastatin and aspirin treatment on carotid plaques, degree of carotid artery luminal narrowing, blood lipid level and recurrence of cerebral infarction were evaluated after12months of treatment.Results:Unstable plaques rate, plaque area and the degree of carotid artery luminal narrowing reduced, and the levels of total cholesterol and low density lipoprotein cholesterol reduced in treatment group after12months of treatment. There were significant differences compared with pre-therapy as well as with control group with P value grater than0.05. The recurrence rate of cerebral infarction within12months in treatment group significantly reduced compared to the control group with P value grater than0.05.Conclusion:The combined therapy of atorvastatin and aspirin enteric-coated tablets could stabilize carotid plaque and reduce the recurrence rate of cerebral infarction within12months.