Evaluation Of Treatment Effect Of Alisma To GK Rats With Diabetic

Objective:By exploring single herb medicine Gliclazide Alismataceae single flavor for the treatment of diabetes, and to evaluate differences between Chinese and Western medicine for the treatment of diabetes.Methods:Select GK rats(Goto-Kakizaki wister rates, GK,Primary rat model of diabetes), will be divided into Alismataceae group, gliclazide group, the control group and normal group (wistar rats). Given two weeks after drug treatment, observation GK weight, food intake, fasting glucose, impaired glucose tolerance and other indicators, comprehensive evaluation of traditional Chinese medicine and western medicine for diabetes treatment differences. Measurement data were expressed in x±s between different treatment groups, at different times, and their interaction were compared using multivariate analysis of variance, multivariate methods were compared using LSD.Result: Alismataceae group decreased two weeks after weight gain (P<0.05). blank group, the normal group, gliclazide group administered two weeks after weight gain (P<0.05). Alisma group decreased compared with the other three groups after administration of body weight(P<0.05) there was no significant difference food intake between the groups and after two weeks (P>0.05). Administered after two weeks Alismataceae group and gliclazide group lower fasting blood glucose (P<0.05),Alismataceae group improved significantly compared to the administration before the drug was administered two weeks after glucose tolerance, compared with the control group, and there are also significantly improved (P<0.05), gliclazide group two weeks after administration of the drug administered glucose tolerance than before and compared to the control group, there was no significant (P>0.05).Conclusion:1. single herb Alisma, there is a very good medicine Gliclazide reduced fasting blood glucose. However, as a single target for the development of western drugs in reducing fasting blood glucose compared to medicine Zexie strong.2.compared with western medicine Alismataceae gliclazide fasting blood glucose control, the same can control weight, improve glucose intolerance, reflecting the traditional Chinese medicine as a mixture Alismataceae for a comprehensive disease can play the advantages of multi-targeted interventions.