Expression And Significance Of Lysyl Oxidase Family Proteins In Human Prostate Cancer Tissues

Prostate cancer is one of the most common malignant tumor of the male urogenital system, its incidence increased year by year, which does great harm to men’s health. So far, the etiology and pathogenesis of prostate cancer has not been elucidated completely.Clinically, patients with prostate cancer often have progressed to advanced stage of the disease and lost the opportunity of radical prostatectomy when they come to the hospital.This seriously affects the quality of life of the patients and eventually leads to their death. Therefore, to investigate the molecular pathway and the mechanism that may be related to the occurrence of prostate cancer has become a research hotspot which can lay the theoretical foundation for prevention,early diagnosis and targeted therapy of prostate cancer.Lysyl oxidase(LOX) is a monoamine oxidase, whose family consists of five members:LOX, LOXL1, LOXL2, LOXL3 and LOXL4.They can stabilize the extracellular matrix(ECM) and maintain the structural integrity of it. In recent years,the study found that the LOX family members also have some other new features and may be associated with the carcinogenesis and development of tumor.Some may be tumor suppressors,while some may promote the occurrence and progress of tumor.However, there are few researches on the different expression of LOX family proteins in prostate cancer and benign prostatic hyperplasia tissues.Objective:Study the expression of lysyl oxidase family(LOX family) proteins in prostate cancer and benign prostatic hyperplasia tissues,analysis whether it has difference,explore the relationship between their expression and the occurrence of prostate cancer, look for the possible etiology and pathogenesis of prostate cancer toprovide a theoretical basis on selecting the biological index for early diagnosis and therapeutic target of prostate cancer.Method:Detect the expression of LOX family(LOX, LOXL1, LOXL2, LOXL3, LOXL4)proteins in 31 cases of prostate cancer tissues and 33 cases of benign prostatic hyperplasia tissues using immunohistochemistry and apply the related statistical methods to analysis whether the difference has statistical significance.Results:1.There is LOX in both cytoplasm and nucleus in the prostate tissues while LOXL1, LOXL2, LOXL3, LOXL4 can be only observed in the cytoplasm of prostate tissues.2.There are significant differences of the expression of LOXL2 and LOXL4 in prostate cancer and benign prostatic hyperplasia tissues(P<0.05).3.The expression of LOXL2 in prostate cancer tissues is significantly lower than that of benign prostatic hyperplasia tissues(P=0.001).4.The expression of LOXL4 in prostate cancer tissues is significantly higher than that of benign prostatic hyperplasia tissues(P=0.003).5.There are no differences of the expression of LOX, LOXL1 and LOXL3 in prostate cancer and benign prostatic hyperplasia tissues(P>0.05).Conclusions:1.There are significant differences in LOXL2 and LOXL4 expression in prostate cancer and benign prostatic hyperplasia tissues(P<0.05), which are probably associated with the occurrence of prostate cancer.2.The expression of LOXL2 in prostate cancer tissues is significantly lower than that in benign prostatic hyperplasia tissues(P=0.001), which probably acts as an inhibitory factor during the course of occurrence of prostate cancer.3.The expression of LOXL4 in prostate cancer tissues is significantly higher than that in benign prostatic hyperplasia tissues(P=0.003), which may be a promoting factor during the process of occurrence of prostate cancer...