The Observation Of The Clinical Efficacy Of Applying The Shuyu Di Shao Decotion In Primary Sjogren’s Syndrome

Objectives:To observe the clinical efficacy and safety of applying the Decocting of Shuyu Di Shao on primary Sjogren’s syndrome (pSS),and to explore the etioligy,pathogenesis,clinical manifestation and therapeutic principle of Spleen Yin deficiency syndrome. Methods:58 patients with syndrome of Spleen Yin deficiency of pSS are involved in this research, being divided 31 patients to the treatment group,28 to the control group. The treatment group is prescribed Chinese medicine decoction named the prescription with Shuyu Di Shao which is taken twice daily, and two pills of hydroxychloroquine(HCQ) sulfate (0.1g) are given to the control group per day during the whole treatment period of 12 weeks. All patients are evaluated about cardinal scores of TCM symptoms on the first,4th,8th and 12ed week respectively.Meanwhile,the EULAR Sjogren’s Syndrome Patients Reported Index(ESSPRI),EULAR Sjogren’s syndrome disease activity index(ESSDAI),living quality,heslth condition,fatigue severity scores(FSS),immune and inflammatory index are compared after each course.Result:The total rate of positive results in treatment group is 86.7%,64.3% in control group, with statistical significance in differece(P<0.05); After the therapy, the scores of TCM symptoms, ESSPRI, SF-36 and FSS are improved significantly (P<0.01), with the better improvement level in the treatment group (P<0.05), especially in improving the cardinal TCM symptoms; Moreover, after the treatment, the ESSDAI, white blood cells(WBC), erythrocyte sedimentation rate(ESR), C-Reactive protien(CRP) andImmunoglobulin G(IgG) are also significantly improved(P<0.05), but the differences between two groups are statistically insignificant(P>0.05). It is also interesting to notice that the IgG had improved dramatically after the therapy in the control group(P<0.01).Conclusion:Applying the Decocting of Shuyu Di Shao,based on the method of tonifying qi to invigorate the spleen and nourishing yin using with promoting the secretion of fluid,for pSS patients had better improved the effect of treatment significantly than HCQ, which also had improved the symptom of patients and enhanced their life qualities. What’s more, it also controls the index of activity of disease and ameliorate the laboratory, being a steady and safe method in short period.