The Clinical Research For Primary Biliary Cirrhosis Of Spleen Deficiency And Blood Stasis Type Treated With Bear Bile Acid To Oxygen Combine Righting、transform Stasis And Cholagogic

Objective:To seek more effective treatment options for primary biliary cirrhosis(primary biliary,cirrhosis,PBC) of spleen deficiency and blood stasis type,the control group is treated with ursodeoxycholic acid(ursodeoxycholic,acid,UDCA) as the conventional treatment,and the treatment group is based on the conventional treatment treated with traditional Chinese medicine cholagogue righting transform stasis,to observe the effect of clinical symptoms of the disease of traditional Chinese Medicine,ElastPQ mean,liver function,Routine blood test,Urine routine,Stool test,Renal function,electrocardiogram etc,and analyse the Clinical significance and safety of the method of cholagogue righting transform stasis.Method:All the PBC patients. are selected from January 2014 to December 2014 in traditional Chinese Medicine Hospital of Jiangsu Province’s Communicable Disease Department, Including outpation and ward hospitalized patients,then the 40 PBC patients who meeted the study inclusion criteria are randomly divided into 2 groups,namely,treatment group and control group.The control group is treated with simply UDCA treatment,and the treatment group is based on the conventional treatment treated with traditional Chinese medicine cholagogue righting transform stasis,the time of treatment is 6 months,and use the SPSS17.0 statistical analysis,to observe and recorde the changes of patients’s liver function and symptoms and ElastPQ mean before and after the treatment,then analysis the curative effect.To obsever the changes in patients with blood,urine stool,ECG and renal function and other safety indicators before and after the treatment,then analysis the safety of efficacy.Result.(1) The treatment group clinical cure in 0 cases,5 cases were markedly effective,12 cases effective,total effective rate was 85%;The control group clinical cure 0 cases,2 cases were markedly improved,effective 9 cases,total effective rate was 55%.Overall curative effect of treatment group was better than control group,the comparison between the two groups have significant difference (P<0.05).(2) The total score of TCM syndromes in the two groups was statistically significant after the treatment(P<0.05).(3) After the treatment both of the two group’s patients’alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP), gamma archaeal ammonia acyl turn peptidase (y-GT),serum total bilirubin (TB) decreased,before and after treatment,the patients in the two groups compared the differences were statistically meter significance. (P<0.05);The comparison of liver function index of the two groups of patients before and after treatment,the difference was statistically significant(P<0.05),but except for TB(P>0.05)(4) The comparion of the two groups’ ElastPQ mean before and after the treatment,was statistically significant (P<0.05);The comparion of mean ElastPQ of the two groups of patients after treatment,the difference was statistically significant(P<0.05).(5) Two groups of patients during treatment does not appear obvious adverse reactions, treatment before and after the detection of blood, stool routine ECG and renal function did not appear abnormal changes associated with the drug.Conclusion:cholagogue righting transform stasis method combined with UDCA treat the spleen deficiency and blood stasis type of PBC,improve liver function in patients with index,liver stiffness values and clinical symptoms is better than single use of UDCA,and is side effect.