The Clinical Observation Of The Therapy Of Clearing Heat And Dissipating Dampness In Treatment Of Acute Gouty Arthritis

Objective:This study with confirmed cases of acute gouty arthritis considered as research object is aimed to take the pre and post therapeutic TCM syndrome integral,laboratory indexes and so on,using the prescription,gouty prescription,of Chinese medicine master Zhou Zhongying,to preliminary conclude and evaluate the efficacy and safety of the therapy of heat-clearing-dampness-dissipating and blood-circulation-promoting-meridian-obstruction-removing in the treatment of dampness-heat stagnancy type of Acute gouty arthritis and provide the basis of TCM Treatment of the disease.Method:To divide the 70 patients accordance with the inclusion criteria of dampness-heat stagnancy type of acute gout arthritis patients into two groups:the treatment group and the control group with 35 cases in each group.The treatment group took the chinese native of gouty prescription(twice a day) and colchicine(0.5mg once,twice a day),whereas the control group was given colchicine 0.5mg once,twice a day.To evaluate the efficacy of two groups with 2 weeks as an observation cycle by comparing their therapeutic clinical efficacy,TCM syndrome integral, VAS score of arthralgia,ESR,CRP,BUA,etc.Results:1.TCM syndrome integral:There was no statistically significant difference in TCM syndrome integral before treatment between two groups(P> 0.05).There was statistically signifycant difference in the TCM syndrome integral before arid after treatment whin each group (P<0.01).There was statistically significant difference in TCM syndrome integral after treatment between two groups(P< 0.05).TCM syndrome integral of the treatment group(6.40± 2.51)was statistically lower than the control group(8.45±1.87),especially in arthralgia,Heavy tired,Short yellow urine(P< 0.01)and arthrocele(P< 0.05).2.VAS score of arthralgia:There was no statistically significant difference in VAS score of arthralgil before treatment between two groups(P> 0.05).There was statistically significant difference in the VAS score of arthralgia before arid after treatment whin each group (P< 0.01). There was no statistically significant difference in VAS score of arthralgia after treatment between two groups(P> 0.05).3.Laboratory indexes:(1)There was no statistically significant difference in BUA before treatment between two groups(P> 0.05).There was statistically significant difference in the BUA before arid after treatment whin each group(P< 0.01). There was statistically significant differrence in BUA after treatment between two groups(P< 0.05). BUA of the treatment group(448.55±57.10μmol/L) was statistically lower than the control group(460.86± 62.09μmol/L).(2)There was no statistically significant difference in ESR before treatment between two groups(P> 0.05).There was statistically significant difference in the ESR before arid after treatment whin each group(P< 0.01). There was no statistically significant difference in ESR after treatment between two groups(P> 0.05).(3)There was no statistically significant difference in CRP before treatment between two groups(P> 0.05).There was statistically significant difference in the CRP before arid after treatment whin each group(P< 0.01). There was no statistically significant difference in CRP after treatment between two groups(P> 0.05).4.The clinical efficacy:Total effective rate in the treatment group and the control group was 94.29% and 77.14%,respectively.Clinical cure rate was 8.57%(3 cases) and 2.86%(1 case),marked effect rate was 48.57%(17 cases) and 42.86%(15 cases), effective rate was 37.14%(13 cases) and 31.43%(11 cases),ineffective rate was 5.71%(2 cases) and 22.86%(8 cases),respectively.There was statistically significant difference in the therapeutic total effective rate after treatment between two groups(P< 0.05).5.The safety:Total Adverse Reactions of the treatment group and the control group was 3 cases and 12 cases,respectively.Including gastrointestinal reaction was 2 cases and 5 cases,abnormal liver and kidney functions was 1 case and 4 cases,abnormal blood routine was 0 case and 3 cases,respectively.There was statistically significant difference in the therapeutic total effective rate after treatment between two groups(P< 0.01).Conclusion:The results prove that the therapy of heat-clearing-dampness-dissipating and blood-circulation-promoting-meridian-obstruction-removing significant improve TCM syndrome integral,VAS score of arthralgia,BUA,ESR,CRP of dampness-heat stagnancy type of Acute gouty arthritis.Especially, TCM syndrome integral(arthralgia,Heavy tired,Short yellow urine,arthrocele),BUA of the treatment group was statistically lower than the control group.But VAS score of arthralgia,ESR,CRP were no difference. Besides, the therapeutic total effective in the treatment group was statistically lower than the control group. So, the therapy of heat-clearing-dampness-dissipating and blood-circulation-promoting-meridian-obstruction-removing is an effective treatment of dampness-heat stagnancy type of Acute gouty arthritis.