Research On Undergraduate Students’ Depression Impacts On The Brain Function Of Reward System

Depression is one of the most global threatening disease in recent years. Depression is the second disease following cancer, which is threaten to human life. Therefore, the early diagnosis of depression is great significance to explore of pathologies and the treatment of mental illness. Currently, fMRI as the most promising measurement for brain nondestructive testing, it can help us to get quality signal of living brain. It is indicated a new direction for the patterns concluding of information processing in the brain and diagnosis of preliminary depression.In this article to utilize functional magnetic resonance imaging (fMRI), based on the research of depression in college students, the effectiveness in the reward system of different students within Normal and Depression is researched. In this paper, it will be studied by the distributed of brain activation, proceeding from both reward-functional state and resting state fMRI data to compare the difference in processing mode of reward system under depression objects and normal objects, the control objects group. The experimental method are adopted with event-related gambling task paradigm to research the effect of reward processing system between depression group and control group.In this paper, two sets of brain cognitive experiments are performed, which are resting experiments and gambling task reward experiments. To analysis the connectivity networks and brain activity region, the impact of depression could be shown. For the resting state, there are three methods to analysis the correlation of various brain regions, ALFF, ReHo and FC. For the functional state of reward, generalized linear model (GLM) algorithm. GLM method clearly show brain activity areas.The resting-state results are shown that the resting generated negative emotions of depression group subjects are stronger than that of control group, but the inhibitory activation brain areas of reward system are weaker than that of control group. Results during the gambling task reward experiments show that depression group also activate reward circuits inadequate.