Clinical Study On The Correlation Between The Extent Of Coronary Artery Lesions And The Blood Turbidity Syndrome Of Traditional Chinese Medicine In Patients With Coronary Heart Disease

Objective: This research is aimed at analyzing the correlation between the extent of coronary artery lesions in patients with Coronary Heart Disease(CHD) and both the extent and types of syndrome in the blood turbidity. And then explore the effects of blood turbidity syndrome of CHD, the relationship between each syndrome of blood turbidity and coronary artery lesions, in order to provide a theoretical basis and objective evaluation index of diagnosis and treatment from the blood turbidity theory, and finally figure out the diagnostic criteria of blood turbidity syndrome and the feasibility of the objective.Methods: This study selected 90 patients who suffered the coronary artery disease.They were all in Cardiology clinics and wards from October of 2014 to February of 2015 Qilu Hospital of Shandong University. 30 cases of healthy have been added as a group under control. Blood turbidity syndrome and various syndrome rating scale was designed to assesses the evaluation of blood turbidity degree of patients, analysis of CAG in patients with observation. Through the comparison between groups of blood turbidity degree analysis, of TCM analysis of the correlation between syndrome and coronary Gensini score with blood turbidity, the relationship between the severity of coronary lesions in patients with coronary heart disease and TCM syndrome of turbid blood and also the differences between them can both be explored then.Results:1.The study contained 90 cases of coronary heart disease patients, 15 patients of them suffered the qi stagnation, 12 of them suffered toxic heat, 9 of them suffered the cold coagulation, 21 patients suffered dampness, and the last 33 patients suffered the deficiency of vital qi.2.The patients with blood turbidity who also suffered the deficiency of vital qi were older than the patients in other groups(all P<0.05);The BMI of patients with blood turbidity combined with dampness group were higher than the BMI from patients in other groups with significant differences(all P<0.05).3.In the blood turbidity syndrome of TCM groups, the plasma TC, TG, LDL-C levels were significantly higher than the level of the control group(all P<0.01);the plasma TC levels of the patients with dampness blood turbidity syndrome were clearly higher than the level of those who suffered the blood turbidity with qi stagnation, toxic heat and cold coagulation(all P<0.05); the plasma HDL-C levels of the patients with blood turbidity were lower compared with the control group(all P<0.05);4.The plasma FIB levels of the patients with blood turbidity were higher than the healthy control group(all P<0.05); the plasma DD-i levels of the patients with blood turbidity were higher than the healthy control group, but the difference was not statistically significant(all P>0.05);5.The plasma FBG levels of the patients with blood turbidity were higher than healthy control group(all P<0.05);the plasma Hcy levels of patients with blood turbidity were significantly higher than the healthy control group(all P<0.01);the plasma Hcy levels of the patients with blood turbidity combine with deficiency of vital qi and dampness were higher than other groups(all P<0.05); Lastly, the plasma Hcy levels of the patients with blood turbidity in toxic heat and cold coagulation were higher than the patients with blood turbidity in qi stagnation;6.The degree of blood turbidity was also progressing(P<0.05/P<0.01);correlative analysis showed that there was a significantly positive correlation between the Gensini score and the blood turbidity score(r=0.739,P<0.01),and there was also a positive correlation between Gensini score and ages/BMI(r=0.573,P<0.05;r=0.553,P<0.05);a positive correlation between the Gensini score and the score of the blood turbidity combine with toxic heat(r=0.625,P<0.05)is also shown according to the data, and there were positive correlations between the Gensini score and the score of the blood turbidity with cold coagulation, dampness and deficiency of vital qi(r=0.673,r=0.803,r=0.884;all P<0.01)as well. However, there was no correlation between the Gensini score and the score of the blood turbidity in qi stagnation;Conclusions:1.The phenomenon of coronary heart disease in patients with blood turbidity,which combined deficiency of vital qi was the most common, and this was more common to see in the older-patients group, blood turbidity combined with dampness was also more common among some fatter patients;2.The plasma lipids, FIB,FBG and Hcy levels of CHD patients with blood turbidity lipid levels were higher compared with the level of the healthy persons, the plasma TC levels of the patients with dampness blood turbidity were significantly higher than other blood turbidity patients; on the other hand,the plasma Hcy levels in patients with blood turbidity combine with dampness and deficiency of vital qi were also higher than other patients;3.There was a significantly positive correlation between coronary artery disease lesions the extent of blood turbidity,the boold turbidity maybe the basis pathological of the coronary artery lesions;The rating scales we redesigned in this study can provide the objective diagnostic evidence for the diagnosis of coronary heart disease blood turbid syndrome.