Altered Brain Network Centrality In Depression I N Parkinson’s Disease Patients:a Resting-State Functional Magnetic Resonance Imaging Study

Objective:Depression is a relatively common and severe non-motor symptom of Parkinson’s disease (PD), which reduces the quality of patients’life. Although disturbances in some related brain networks have been reported, the pathophysiology of depression in PD (dPD) is still unclear. Here, we investigated the whole brain functional connectivity patterns in dPD patients by using igenvector centrality mapping technology of resting-state functional magnetic resonance imaging (rsfMRI), aiming to explore the pathophysiology of dPD further.Method:We recruited17PD patients suffered from major depressive disorder, which was diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders,4th edition (DSM-Ⅳ) criteria and17PD patients without depression (ndPD) and17age and sex matched normal control subjects (NCs). Resting-state functional magnetic resonance imaging and eigenvector centrality mapping were used to identify functional connectivity alterations among these groups. Two sample t-test was used to detect the brain regions with abnormal functional connectivity.Result:The results showed that dPD patients had decreased functional connectivity in the left dorsolateral prefrontal cortex and right superior temporal gyrus, and increased functional connectivity in the right posterior cingulate cortex compared to ndPD patients. In addition, there was a significant negative correlation between functional connectivity and depression scores in the posterior cingulate cortex.Conclusion:This study suggests that functional connectivity changes in certain nodes of brain networks, such as dorsolateral prefrontal cortex, superior temporal gyrus, posterior cingulate cortex and so on, might contribute to depression in PD.