The Impact Of Risperidone On Sleep’s Character Of Male With First-episode Schizophrenia

BackgroundSchizophrenia often associated with sleep disorders, the incidence of which is as high as 30～80%. Long lasting sleep disorders can affect the treatment effect, even may lead to suicide for schizophrenia patients.Objectives1. To explore the characteristics of the sleep in patients with schizopheria.2. To investigate the impact of risperidone on sleep in patients with schizophrenia.Methods1. There were two groups, thirty patients diagnosed firstly as schizophrenia without treating according to DSM-Ⅳ, in the study group; thirty healthy people in the control one, they are all male, and there is no difference on age.2. The study group only took risperidone as the therapy. They were all analyzed using PANSS, before and 3 weeks after the treatment.3. Record the description of Polysomnogram(PSG) of the study group twice, before and 3 weeks after the treatment, mainly including the total sleep time(min), the latency of sleep(min), the efficiency of sleep(%), the awaken time(min), the latency of rapid-eye-movement sleep(min), the time of rapid-eye-movement sleep(min), S1(min), S2(%), S3+S4(%). The controls only record once.4. SPSS17.0 was used for statistical analysis of the data. t test was performed for the indicator’s of PANSS and GSP.The standard value of significant difference was α=0.05.Results1. Each index score in PANSS scale of after taking the risperidone is lower than before taking the risperidone.Positive symptoms, negative symptoms, pathological symptoms and the total score,the t was 30.17、22.63、22.67、30.17, respectively,P<0.05.2. Compared with the healthy control group,the study group before taking the risperidone has a shorter sleep time and a poorer sleep quality. Total sleep time,sleep latency,sleep efficiency, awakening time, rapid eye movement sleep latency period, rapid eye movement sleep time,S1,S3+S4,the t was 31.43、-3.93、7.05、-11.92、8.15、15.67、-14.85、20.86, respectively,P<0.05.3. Compared with every index in Polysomnogram before taking the risperidone of the study group.In three weeks,the study group after taking the risperidone has a longer sleep time and a better sleep quality.Total sleep time, sleep efficiency, awakening time and rapid eye movement sleep latency period, rapid eye movement sleep time, S1, S2,the t was 21.209,11.729,6.571,6.571,7.176,11.258,11.258, respectively,P<0.05.4. Compared with Pittsburgh sleep quality index,PSQI before taking the risperidone of the study group.In three weeks,the study group after taking the risperidone,Patients’ subjective feeling sleep time was longer,and sleep quality has improved obviously.Subjective sleep quality, time for falling asleep, sleep time, dyssomnia, sleep efficiency, sleep medication, daytime function, PSQI scores,the t was 21.209,11.729, 6.571,6.571,7.176,11.258,11.258, respectively,P<0.05.Conclusions1. Patients with schizophrenia have a sleep disorder, Shorten sleep time and worse sleep quality.2. Risperidone can improve sleep in patients with schizophrenia, can prolong the sleep time, improve the quality of sleep.