| Background:Bronchial asthma is a pediatric respiratory disease that most common in ch ildren, which relapses easily, and impacts children’s physical and mental health seriously, the morbidity and mortality of asthma is increasing year by year in children. Bronchial a sthma is chronic inflammatory disease of the airway,which is caused by a lot kinds of ce lls, containing inflammatory cells, airway structural cells and cellular components. This kind of chronic airway inflammation makes the susceptible individuals airway hyperresponsiven ess. When exposed to stimulus,such as physical factors, chemical factors, biological factors and others, changeable reversible airflow occurs, and lead to airway constriction, performan ce for recurrent wheezing, difficulty in breathing, chest tightness or the symptom such as c ough and other symptoms.This disease often attack and aggravate during the night or ear ly morning, most children can ease on their own or by treatment. The onset of this disea se is abruptly, if not treated in a timely manner and effectively, often can be acontinuous s tate of asthma, airway irreversibility constriction, and make the risk of the life. Therefore, br onchial asthma attracks extensive attention of the medical profession. Modern medicine ca n not cure this disease, mainly to control the symptoms and reduce relapse, the drug are di vided into the sugar cortical hormone, bronchodilator ((β2 receptor agonist, theophylline, an ticholinergic drugs, Magnesium sulfate), the inhibitor of release allergic media (sodium cr omoglicate, Tong Tifen), leukotriene receptor antagonist, other drugs(therapy, immune spec ific immune regulator), but the beta 2 agonists can inhibit airway inflammation, and long-term, single use can make the down regulation of cell membrane receptor beta 2 cause drug resistance, cause adverse reactions like skeletal muscle tremor, cardiac arrhythmia an d so on,and short-term use has no obvious relief to cough and expectoration.Systemic ap plication of glucocorticoid can inhibit pituitary-adrenal axis, lead to a lot of adverse react ions, the effective blood drug concentrations of theophylline safety range is very narrow, easy to poisoning, Therefore, traditional Chinese medicine as an economic, convenient, effec tive, and side effects of small treatments become a research hotspot.Object:To observe the influence of decoction of Xichuan with Salbutamol hydrochloride to children with bronchial asthma in the acute mild-to-moderate phase on symptoms, signs and pulmonary function, so as to provide theoretical basis for Chinese medicine treatment of children bronchial asthma.Method:60 children were divided into two groups, including the treatment one and the control one, with 30 cases in each group, the treatment group to Xichuan decoction and Salbutamol hydrochloride,30 cases in the control group were given Salbutamol hydrochlo ride treatment only.a course of one week.To observe the influence of two groups to thos e children with acute athma on clinical symptoms and signs, pulmonary function after tre atment.Results:1. The comparison about total effective rate between the two groups:the rate o f the treatment group was 93.33%,while the control one was 83.33%,the treatment group was better than the control one,the differences were significant (P<0.05)2.After a course of one treatment by xichuan soupgood and Salbutamol hydrochloride,18 children’sympto m of wheezing disappeared in three days,10 children was Obviously alleviate.17 children’ symptom of wheezing sound disappeared. Cough, expectoration, nasal itching and runny n ose, pharyngeal itching, appetite and stool were different when compared with those befor e treatment (P<0.05), no significant differences in other aspects(P>0.05);The control group also had changement on symptoms on cough,nasal itching and sweat(P<0.05), no signifi cant differences in other aspects(P>0.05);the differences between two groups after treatmen t on cough, expectoration, nasal itching, runny nose and appetite was significant (P<0.05), while no significant differences in other aspects(P>0.05).3. After treatment,the lung func tion index such as FEV1,PEF both increased in two groups, the difference was clear (P<0. 05); and the treatment group was previor than the control one on the pulmonary function after treatment by inspection(P<0.05).Conclusion:1 The treatment group(Xichuan decoction and Salbutamol hydrochloride) coul d release patients’breathing and wheezing sound when in acute stage of asthma,it could s ignificantly ameliorate the symptoms than the control group. it also could release sympt ms such as cough, expectoration, nasal itching and runny nose.2 The treatment group coul d significantly improve lung function (FEV1,PEF), and had obvious advantages comparing with the control group.3 Xichuan soupgood has good security, and is is better than routin e western medicine in treating patients with acute asthma in mild or moderate conditio n, and is worthful to observe in clinical application. |
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